RECTAS

Name: RECTAS
Brand: Tocris Bioscience
SKU: 7679

Tocris Bioscience, part of Bio-Techne | Catalog # 7679

COA / SDS

IKBKAP pre-mRNA splicing modulator

Key Product Details

Description:	IKBKAP pre-mRNA splicing modulator
Chemical Name:	2-Chloro-N-(2-furanylmethyl)-7H-purin-6-amine
Purity:	≥98% (HPLC)
Molecular Weight:	249.66

View Full Technical Details for RECTAS

Technical Data
Citations

Biological Activity for RECTAS

RECTAS (rectifier of aberrant splicing) is a pre-mRNA splicing modulator of the IKBKAP (inhibitor of κ light polypeptide gene enhancer in B-cells, kinase complex associated protein) gene. It corrects aberrant IKBKAP splicing in vitro in cellular models of familial dysautonomia and in vivo in transgenic mice. In combination with Phenylbutyric acid (Cat. No. 2682), RECTAS rescues PARK7 aberrant splicing and neuronal cell loss in a midbrain organoid model of familial Parkinson's disease. Orally bioavailable and brain penetrant.

Technical Data for RECTAS

M. Wt	249.66
Formula	C₁₀H₈ClN₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	101862-47-9
PubChem ID	5037694
InChi Key	QGUOPVCOXHVPJX-UHFFFAOYSA-N
Smiles	ClC1=NC=2N=CNC2C(=N1)NCC=3OC=CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RECTAS

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.97	100

Preparing Stock Solutions for RECTAS

The following data is based on the product molecular weight 249.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.03 mL	40.05 mL
5 mM	0.80 mL	4.01 mL	8.01 mL
10 mM	0.40 mL	2.00 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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References for RECTAS

References are publications that support the biological activity of the product.

Yoshida Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proc.Natl.Acad.Sci U.S.A. 2015 PMID: 25675486
Boussaad A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease. Sci.Transl.Med. 2020 PMID: 32908004
Ajiro Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Nat.Commun. 2021 PMID: 34301951