Compounds for Stem Cell Proliferation and Renewal Products
Maintaining stem cells in an undifferentiated state while in culture is important to ensure consistency and reproducibility among experiments. Traditionally, embryonic stem cells have been grown in culture using mouse embryonic fibroblasts as a feeder layer or using defined culture media. For some applications, the addition of small molecules to culture conditions can increase the proliferative capacity of pluripotent stem cells.
For instance, Wnt signaling is known to promote pluripotent stem cell self-renewal, and the Wnt pathway can be activated by BIO, a small molecule that selectively inhibits GSK-3 beta. Similarly, induced pluripotent stem cell self-renewal can be enhanced in vitro by a small molecule that inhibits ALK5, thereby preventing Smad2 phosphorylation and TGF-beta signal transduction. Tocris provides a complete range of bioactive small molecules for the maintenance of self-renewal and proliferation of multiple stem cell types including embryonic, induced pluripotent, neural, and adult stem cells.
Products:
31 results for "Compounds for Stem Cell Proliferation and Renewal" in Products
31 results for "Compounds for Stem Cell Proliferation and Renewal" in Products
Compounds for Stem Cell Proliferation and Renewal Products
Maintaining stem cells in an undifferentiated state while in culture is important to ensure consistency and reproducibility among experiments. Traditionally, embryonic stem cells have been grown in culture using mouse embryonic fibroblasts as a feeder layer or using defined culture media. For some applications, the addition of small molecules to culture conditions can increase the proliferative capacity of pluripotent stem cells.
For instance, Wnt signaling is known to promote pluripotent stem cell self-renewal, and the Wnt pathway can be activated by BIO, a small molecule that selectively inhibits GSK-3 beta. Similarly, induced pluripotent stem cell self-renewal can be enhanced in vitro by a small molecule that inhibits ALK5, thereby preventing Smad2 phosphorylation and TGF-beta signal transduction. Tocris provides a complete range of bioactive small molecules for the maintenance of self-renewal and proliferation of multiple stem cell types including embryonic, induced pluripotent, neural, and adult stem cells.
Products:
Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
| Alternate Names: | y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor |
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity: | ≥99% (HPLC) |
Y-27632 synthesized to cGMP guidelines
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥99% |
SB 431542 synthesized to cGMP guidelines
| Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity: | ≥99% |
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
| Alternate Names: | PGE2 |
| Chemical Name: | (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid |
| Purity: | ≥98% (HPLC) |
Cell culture supplement for improving stem cell survival
Selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name: | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Purity: | ≥98% (HPLC) |
PORCN inhibitor; inhibits Wnt processing and secretion
| Chemical Name: | N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide |
| Purity: | ≥98% (HPLC) |
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
| Chemical Name: | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride |
| Purity: | ≥99% (HPLC) |
Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis
| Chemical Name: | (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
FGFR1 and -3 inhibitor
| Chemical Name: | N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of p38 MAPK
| Chemical Name: | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
| Purity: | ≥98% (HPLC) |
Potent pan-caspase inhibitor
| Chemical Name: | N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide |
| Purity: | ≥98% (HPLC) |
Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds
| Purity: | ≥95% (HPLC) |
MEK inhibitor
| Chemical Name: | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
Potent AMPK activator
| Chemical Name: | 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Purity: | ≥98% (HPLC) |
Sterile-filtered 10 mM solution of Y-27632, selective ROCK inhibitor, pre-dissolved in water
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥97% (HPLC) |
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons
| Chemical Name: | 4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzeneacetamide |
| Purity: | ≥98% (HPLC) |
Minimal recognition sequence for integrin binding; potent integrin inhibitor
| Purity: | ≥95% (HPLC) |
Enhances survival of human ESCs following enzymatic dissociation
| Chemical Name: | N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo
| Chemical Name: | 5-(3-Methoxyphenoxy)-N2-[4-(1-methylethyl)phenyl]-2,4-quinazolinediamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% (HPLC) |
A 83-01 synthesized to Ancillary Material Grade
| Chemical Name: | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Purity: | ≥98% |
Potent GSK-3 inhibitor; also inhibits cdks
| Alternate Names: | 6BIO |
| Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
| Purity: | ≥98% (HPLC) |
