Prostaglandin E₂

Product Description

Prostaglandin E₂ is an endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Prostaglandin E₂ binds with high affinity to EP₁, EP₂, EP₃ and EP₄ receptors (K_d values range between ~ 1 - 10 nM). Prostaglandin E₂ influences a wide range of processes including inflammation, vasodilation, smooth muscle relaxation, fertility, gastric mucosal integrity and platelet aggregation. Prostaglandin E₂ regulates vertebrate hematopoietic stem cell (HSC) homeostasis, acts as viral transduction enhancer and is tumorigenic in some cancers.

Solubility

Preparing Stock Solutions for Prostaglandin E₂

The following data is based on the product molecular weight 352.47

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.19 mL	28.37 mL
5 mM	0.57 mL	2.84 mL	5.67 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Heffner Prostaglandin E₂ increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther 2018 PMID: 29102562
• Ke Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer. Tumour Biol. 2016 PMID: 27230680
• Karthaus Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 2014 PMID: 25201529
• Sato SnapShot: Growing organoids from stem cells. Cell. 2015 PMID: 26091044
• North Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 PMID: 17581586
• Hata and Breyer Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharm.Ther.
• Coleman Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol.Rev. 1994 PMID: 7938166