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SB 203580

Tocris Bioscience a Bio-Techne Brand

p38 Inhibitors Small Molecule
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1202/10
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Key Product Details

Description: Selective inhibitor of p38 MAPK
Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
Purity: ≥98% (HPLC)
Molecular Weight: 377.44

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Citations for SB 203580 (106)

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Customer Reviews for SB 203580 (4)

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  • Combinatorial treatments
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Combinatorial treatments of the p38 MAPK inhibitor with chemotherapeutics led to synergistic apoptotic phenotype in vitro. The product is highly recommended.
  • The role of p38 MAPK signaling in genotoxics-induced stress.
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    SB 203580 was dissolved in DMSO and used at a final concentration of 1, 3 or 10 µM in human cancer cell lines, followed by treatment with genotoxics.
  • Used for Migration assays
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: A549 or MDAMB231
    All MAPK inhibitors (ZM336372: c-RAF inhibitor; UO126: MEK1/MEK2 inhibitor, SB203580: p38 inhibitor) were used at 10 μM
    We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
    SB 203580 Serum 1202
  • The role of p38 MAPK signaling in LPA induced pro-inflammatory phenotype in microglia cells
    Name: Joanna Plastira
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary murine microglia cells
    The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of SB239063 (10µM) or SB203580 (10µM). A series of assays were performed. p38 MAPK inhibition totally decreased the expression of 4 pro-inflammatory transcription factors (here presented: pp65). Both inhibitors worked nicely and the results were consistent.
    SB 203580 Serum 1202

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Product Documents for SB 203580

Certificate of Analysis

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