SB 203580
Tocris Bioscience, part of Bio-Techne | Catalog # 1202
Selective inhibitor of p38 MAPK
Key Product Details
Description
Selective inhibitor of p38 MAPK
Alternative Names
Adezmapimod
Product Description
SB 203580 is a selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit IL-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. SB 203580 is an essential component of medium for maintaining stem cells in naive pluripotent state and can be used to promote expansion of HSCs ex vivo.Water-soluble Salt also available.
Product Specifications
Molecular Weight
377.44
Formula
C21H16FN3OS
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
CAS Number
152121-47-6
PubChem ID
176155
InChI Key
CDMGBJANTYXAIV-UHFFFAOYSA-N
SMILES
CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.44 | 25 |
Preparing Stock Solutions
for SB 203580
The following data is based on the product molecular weight 377.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.60 mL | 52.99 mL | 105.98 mL |
| 1.25 mM | 2.12 mL | 10.60 mL | 21.20 mL |
| 2.5 mM | 1.06 mL | 5.30 mL | 10.60 mL |
| 12.5 mM | 0.21 mL | 1.06 mL | 2.12 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jiang Effects of signaling pathway inhibitors on hematopoietic stem cells. Mol.Med.Rep. 2021 PMID: 33179097
- Gafni Derivation of novel human ground state naive pluripotent stem cells. Nature 2013 PMID: 24172903
- Sato Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells. J.Neurosci.Res. 2008 PMID: 18338804
- Saklatvala Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 1996 PMID: 8636072
- Davies Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 2000 PMID: 10998351
- Borsch-Haubold Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 1998 PMID: 9786874
Product Specific Notices for SB 203580
For research use only
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