SB 203580 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1402

Selective inhibitor of p38 MAPK; water-soluble
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Key Product Details

Description

Selective inhibitor of p38 MAPK; water-soluble

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Product Description

SB 203580 hydrochloride is a water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

Product Specifications

Molecular Weight

413.89

Formula

C21H16FN3OS.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride

CAS Number

869185-85-3

PubChem ID

16760644

InChI Key

WOSGGXINSLMASH-UHFFFAOYSA-N

SMILES

Cl.CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.35 25

Preparing Stock Solutions for SB 203580 hydrochloride

The following data is based on the product molecular weight 413.89

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.66 mL 48.32 mL 96.64 mL
1.25 mM 1.93 mL 9.66 mL 19.33 mL
2.5 mM 0.97 mL 4.83 mL 9.66 mL
12.5 mM 0.19 mL 0.97 mL 1.93 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SB 203580 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 203580 hydrochloride

For research use only

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