SB 203580 hydrochloride
Catalog # 1402 | Tocris Bioscience a Bio-Techne Brand
Selective inhibitor of p38 MAPK; water-soluble
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Key Product Details
Description: | Selective inhibitor of p38 MAPK; water-soluble |
Chemical Name: | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 413.89 |
Citations for SB 203580 hydrochloride (11)
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Citations are publications that use Bio-Techne products. Selected citations for SB 203580 hydrochloride include:
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Li et al.
(2019)
Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
Cell.
179:687
PMID: 31626770 -
Zhang et al.
(2018)
Elevated sodium chloride drives type I IF. signaling in macrophages and increases antiviral resistance.
J Biol Chem.
293:1030
PMID: 29203528 -
Yang et al.
(2017)
Establishment of mouse expanded potential stem cells.
Nature.
550:393
PMID: 29019987 -
Silpanisong et al.
(2017)
Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1.
Am J Physiol Cell Physiol.
313:C207
PMID: 28566491 -
Lukjanenko et al.
(2016)
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
Nat Med.
22:897
PMID: 27376579 -
Edén et al.
(2015)
Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated Ins secretion from human pancreatic islets.
Diabetologia.
58:2563
PMID: 26271343 -
Mans et al.
(2014)
An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
J Neurophysiol.
112:2388
PMID: 25143547 -
Nguyen et al.
(2014)
Transient receptor potential vanilloid type 1 channel may modulate opioid reward.
Neuropsychopharmacology.
39:2414
PMID: 24732880 -
Williams et al.
(2012)
Inhibition of stathmin1 accelerates the metastatic process.
Cancer Res.
72:5407
PMID: 22915755 -
Engel et al.
(2006)
FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction.
Proc Natl Acad Sci U S A.
103:15546
PMID: 17032753 -
Schlemper et al.
(2005)
Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro.
Br J Pharmacol.
145:740
PMID: 15852038
There are no citations that match your criteria.
Customer Reviews for SB 203580 hydrochloride (4)
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Species: MouseAssay Type: In VitroCell Line/Tissue: EPS10uM
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Species: MouseAssay Type: In VitroCell Line/Tissue: BV2 microglia cellsWe investigate the effect of LPA on microglia metabolic states. Trying to unravel possible pathways that maybe involved in this process, we used LPAR inhibitors and downstream inhibitors of MAPKs pathway. SB 203580 was used at a concentration of 10µM yet couldn't inhibit the expression of pAMPK. However the inhibitor was well tolerated by the cells.
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Species: HumanAssay Type: In VitroCell Line/Tissue: OsteosarcomaMG-63 cells were pre-incubated with 10 µM SB 203580 for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. SB 203580 inhibited COX-2 induction by LPA.
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Species: MouseAssay Type: In VitroCell Line/Tissue: HL-1 cardiomyocytesHL-1 cells were incubated with p38 MAPK inhibitor (10 µM SB203580, 25 µMPD169316) or p42/44 MAPK kinase inhibitor (25 µM PD98059) for 30 min prior to 15dPGJ2 treatment (15 µM, 1 h). Immunoreactive bands for pp38 and pp42/44 MAPK expressions were followed by Western blot. SB203580 completely inhibited 15d-PGJ2 induced p38 phosphorylation (shown in Image).
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