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SB 203580 hydrochloride

Tocris Bioscience a Bio-Techne Brand

SB 203580 hydrochloride | CAS No. 869185-85-3 | Selective inhibitor of p38 MAPK; water-soluble
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1402/10
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Key Product Details

Description: Selective inhibitor of p38 MAPK; water-soluble
Chemical Name: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride
Purity: ≥98% (HPLC)
Molecular Weight: 413.89

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Citations for SB 203580 hydrochloride (11)

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Customer Reviews for SB 203580 hydrochloride (4)

4.8 out of 5
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  • Generation of EPS-blastoids
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: EPS
    10uM
    SB 203580 hydrochloride Serum 1402
  • p38 MAPK pathway does not influence the LPA induced AMPK phosphorylation in microglia cells.
    Name: lisha joshi
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: BV2 microglia cells
    We investigate the effect of LPA on microglia metabolic states. Trying to unravel possible pathways that maybe involved in this process, we used LPAR inhibitors and downstream inhibitors of MAPKs pathway. SB 203580 was used at a concentration of 10µM yet couldn't inhibit the expression of pAMPK. However the inhibitor was well tolerated by the cells.
    SB 203580 hydrochloride Serum 1402
  • SB 203580 ameliorates LPA-induced COX-2 expression
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    MG-63 cells were pre-incubated with 10 µM SB 203580 for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. SB 203580 inhibited COX-2 induction by LPA.
    SB 203580 hydrochloride Serum 1402
  • SB 203580 blunts 15d-PGJ2 induced pp38 expression
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HL-1 cardiomyocytes
    HL-1 cells were incubated with p38 MAPK inhibitor (10 µM SB203580, 25 µMPD169316) or p42/44 MAPK kinase inhibitor (25 µM PD98059) for 30 min prior to 15dPGJ2 treatment (15 µM, 1 h). Immunoreactive bands for pp38 and pp42/44 MAPK expressions were followed by Western blot. SB203580 completely inhibited 15d-PGJ2 induced p38 phosphorylation (shown in Image).
    SB 203580 hydrochloride Serum 1402

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Product Documents for SB 203580 hydrochloride

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