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LY 294002 hydrochloride

Tocris Bioscience a Bio-Techne Brand

PI 3-Kinase Inhibitors Small Molecule
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Key Product Details

Description: Prototypical PI 3-kinase inhibitor; also inhibits other kinases
Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity: ≥99% (HPLC)
Molecular Weight: 343.81

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Citations for LY 294002 hydrochloride (115)

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Customer Reviews for LY 294002 hydrochloride (5)

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  • PI3K inhibition decreased the LPA induced expression of pAMPK.
    Name: lisha joshi
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: BV2 microglia cells
    BV2 microglia cells were incubated for one hour with 10µM LY294002 prior to treatment with 1µM LPA. Western blot analysis revealed a possible role for PI3K in the LPA induced expression of pAMPK.
    LY 294002 hydrochloride Serum 1130
  • LY 294002 blocks LPA-mediated COX-2 expression
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Human osteosarcoma cells were incubated with 10 μM LY 294002 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. LY 294002 abolished LPA-induced COX-2 expression.
    LY 294002 hydrochloride Serum 1130
  • LY 294002 inhibits 15d-PGJ2-induced Akt phosphorylation
    Name: Christopher Trummer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MG-63 osteosarcoma cells
    MG-63 cells were incubated with PD169316 (25 μM), LY294002 (10 μM) or Akt-1/2 (5 μM Akt-I) for 30 min prior to 15d-PGJ2 treatment (20 μM) for 1 h to follow pAkt expression using Western blot. Akt-1/2 completely blocked 15d-PGJ2-induced Akt phosphorylation in MG-63 cells.
    LY 294002 hydrochloride Serum 1130
  • Successfull PI 3-kinase inhibitor
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: CHO K1
    I used LY294002 hydrochloride 10µM to inhibit pAKT response of FFAR GPCR activators (15min 37°C).
  • Reduction of Foxo1 phosphorylation in cultured theca cells by LY294002.
    Name: Zhenmin Lei
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Ovarian theca cells
    Mouse ovarian theca cells isolated from 60-day old mice were used. Cultured Ptenfl/fl and tPtenMT ovarian theca cells were pretreated with vehicle (DMSO), LY294002 (50 mM), or API-2 (7.5 mM) for 1 h before the addition of LH (50 ng/mL) for 30 min. Western blotting was used to detect Foxo1 phosphorylation in cultured ovarian theca cells.
    LY 294002 hydrochloride Serum 1130

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Product Documents for LY 294002 hydrochloride

Certificate of Analysis

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