Key Product Details
Description: | Potent GSK-3 inhibitor; also inhibits cdks |
Alternative Names: | 6BIO |
Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 356.17 |
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Citations for BIO (18)
Citations are publications that use Bio-Techne products. Selected citations for BIO include:
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Fleskens et al.
(2019)
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells.
Cell Rep.
26:3600
PMID: 30917315 -
Volpini et al.
(2018)
Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages.
Front Immunol.
9:859
PMID: 29743880 -
Diamantopoulou et al.
(2017)
TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
Cancer Cell.
31:621
PMID: 28416184 -
Roy et al.
(2017)
Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration.
Dev Biol.
431:321
PMID: 28887016 -
Stevens et al.
(2017)
Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs.
Development.
144:1283
PMID: 28219948 -
Duffy et al.
(2016)
Wnt signalling is a bi-directional vulnerability of cancer cells.
Oncotarget.
7:60310
PMID: 27531891 -
Zhang et al.
(2015)
GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
PLoS Biol.
13:e1002129
PMID: 25860027 -
Penas et al.
(2015)
GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.
Nat Commun.
14:417
PMID: 25616418 -
Rhim et al.
(2015)
A High-content screen identifies compounds promoting the neuronal differentiation and the midbrain DA neuron specification of human neural progenitor cells.
Elife.
5:16237
PMID: 26542303 -
Lindström et al.
(2015)
Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron.
Nat Chem Biol.
3:e04000
PMID: 25647637 -
Thorne et al.
(2015)
GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.
Stem Cells Transl Med.
11:58
PMID: 25402767 -
Efthymiou et al.
(2015)
Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
Elife.
4:230
PMID: 25637190 -
Pronobis et al.
(2015)
A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction.
Cell.
4:e08022
PMID: 26393419 -
Berger et al.
(2014)
PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.
Cell Cycle.
28:629
PMID: 24263804 -
Lu et al.
(2014)
Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway.
Sci Rep.
5:5368
PMID: 25371059 -
Naujok et al.
(2014)
Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.
BMC Res Notes.
7:273
PMID: 24779365 -
Duffy et al.
(2014)
GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling.
Mol Cancer Ther.
13:454
PMID: 24282277 -
Guo et al.
(2012)
Slug and Sox9 cooperatively determine the mammary stem cell state.
World J Gastroenterol.
148:1015
PMID: 22385965
There are no citations that match your criteria.