BIO
Tocris Bioscience, part of Bio-Techne | Catalog # 3194
Potent GSK-3 inhibitor; also inhibits cdks
Key Product Details
Description
Potent GSK-3 inhibitor; also inhibits cdks
Alternative Names
6BIO
Product Description
BIO is a potent ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 5 nM). Also inhibits cyclin-dependent kinases (cdks; IC50 values are in vitro; also promotes proliferation and dedifferentiation in cardiomyocytes.Negative Control also available.
Product Specifications
Molecular Weight
356.17
Formula
C16H10BrN3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2'Z,3'E)-6-Bromoindirubin-3'-oxime
CAS Number
667463-62-9
PubChem ID
5287844
InChI Key
WNWSUJQVZJJGLF-SQFISAMPSA-N
SMILES
O/N=C(C1=CC=CC=C1N2)/C2=C3/C(NC4=C3C=CC(Br)=C4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.56 | 10 | |
| Ethanol | 3.56 | 10 |
Preparing Stock Solutions
for BIO
The following data is based on the product molecular weight 356.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.08 mL | 140.38 mL | 280.76 mL |
| 0.5 mM | 5.62 mL | 28.08 mL | 56.15 mL |
| 1 mM | 2.81 mL | 14.04 mL | 28.08 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
- Polychronopoulos Structural basis for the synthesis of indirubins as potent and selective inhibtors of glycogen synthase kinase-3 and cyclin dependent kinases. J.Med.Chem. 2004 PMID: 14761195
- Tseng The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem.Biol. 2006 PMID: 16984885
- Meijer GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 2003 PMID: 14700633
Product Specific Notices for BIO
For research use only
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