MeBIO

Name: MeBIO
Brand: Tocris Bioscience
SKU: 3873

Tocris Bioscience a Bio-Techne Brand

Catalog # 3873

Citations (2)

COA / SDS

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Key Product Details

Description:	Inactive analog of BIO (Cat. No. 3194)
Chemical Name:	(2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime
Purity:	≥99% (HPLC)
Molecular Weight:	370.2

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Biological Activity for MeBIO

MeBIO is a control analog of 6-bromoindirubin-3'-oxime (BIO). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC₅₀ values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Active Analog also available.

Technical Data for MeBIO

M. Wt	370.2
Formula	C₁₇H₁₂BrN₃O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	667463-95-8
PubChem ID	24906281
InChi Key	WWVVQXIBSZPELF-UHFFFAOYSA-N
Smiles	O/N=C(C1=CC=CC=C1N2)/C2=C3/C(N(C)C4=C3C=CC(Br)=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MeBIO

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.7	10

Preparing Stock Solutions for MeBIO

The following data is based on the product molecular weight 370.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.01 mL	135.06 mL	270.12 mL
0.5 mM	5.40 mL	27.01 mL	54.02 mL
1 mM	2.70 mL	13.51 mL	27.01 mL
5 mM	0.54 mL	2.70 mL	5.40 mL

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References for MeBIO

References are publications that support the biological activity of the product.

Knockaert Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 2004 PMID: 15077192
Polychronopoulos Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 2004 PMID: 14761195
Meijer GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 2003 PMID: 14700633

Citations for MeBIO (2)

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Citations are publications that use Bio-Techne products. Selected citations for MeBIO include:

Volpini et al. (2018) Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages. Front Immunol. 9:859
PMID: 29743880
Diamantopoulou et al. (2017) TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 31:621
PMID: 28416184

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Product Documents for MeBIO

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.