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PD 98059

Tocris Bioscience a Bio-Techne Brand

MEK Inhibitors Small Molecule
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Key Product Details

Description: MEK inhibitor
Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Molecular Weight: 267.28

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Citations for PD 98059 (96)

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Customer Reviews for PD 98059 (4)

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  • PD 98059 abrogated the LPA induced phosphorylation of AMPK.
    Name: lisha joshi
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: BV2 microglia cells
    We investigate the effect of LPA on microglia metabolic states. Trying to unravel possible pathways that maybe involved in this process, we used inhibitors of MAPKs pathway. Inhibition of ERK (PD 98059; 10µM) decreased the LPA induced activation of pAMPK (among other proteins).
    PD 98059 Serum 1213
  • The role of ERK pathway in LPA induced pro-inflammatory phenotype in microglia cells
    Name: Joanna Plastira
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary murine microglia cells
    The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of PD98059 (10µM) or PD184352 (10µM). A series of assays were performed. Inhibition of ERK pathway didn't seem to play a role in the LPA induced phenotype (here presented: pp65).
    PD 98059 Serum 1213
  • PD 98059 inhibits 15d-PGJ2 induced pp42/44 expression
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HL-1 cardiomyocytes
    HL-1 cells were incubated with p38 MAPK inhibitor (10 µM SB203580, 25 µMPD169316) or p42/44 MAPK kinase inhibitor (25 µM PD98059) for 30 min prior to 15dPGJ2 treatment (15 µM, 1 h). Immunoreactive bands for pp38 and pp42/44 MAPK expressions were followed by Western blot. PD98059 completely inhibited 15d-PGJ2 induced p42/44 phosphorylation (shown in Image).
    PD 98059 Serum 1213
  • Inhibition of MEK in ovarian theca cells by PD98059
    Name: Zhenmin Lei
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Ovarian theca cells
    Used to treat mouse ovarian theca cells to inhibit MEK and detected by Western blot.

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Product Documents for PD 98059

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