Cyclo(-RGDfK)

Name: Cyclo(-RGDfK)
Brand: Tocris Bioscience
SKU: 8917

Tocris Bioscience, part of Bio-Techne | Catalog # 8917

COA / SDS

Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds

Key Product Details

Description:	Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds
Purity:	≥95% (HPLC)
Molecular Weight:	603.68

View Full Technical Details for Cyclo(-RGDfK)

Technical Data
Citations

Biological Activity for Cyclo(-RGDfK)

Cyclo(-RGDfK) is a cyclic peptide, potent integrin inhibitor (IC₅₀ values are 2.3 and 55 nM for αvβ3 and αvβ6, respectively). Cyclo(-RGDfK) improves human pluripotent stem cell (hPSC) adhesion and proliferaton on 3D cell culture synthetic surfaces. Can also be used to target fluorophores and cargo to cancer cells as αvβ3 integrin is upregulated on cancer cells.

Technical Data for Cyclo(-RGDfK)

M. Wt	603.68
Formula	C₂₇H₄₁N₉O₇
Single Letter Sequence	RGDFK (Modifications: Lactam bridge: Arg-1 to Lys-5, Phe-4:D-Phe)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	161552-03-0
PubChem ID	10196873
InChi Key	NVHPXYIRNJFKTE-HAGHYFMRSA-N
Smiles	O=C(NCC(N[C@@H](CC(O)=O)C(N[C@H](CC1=CC=CC=C1)C(N[C@H]2CCCCN)=O)=O)=O)[C@H](CCCNC(N)=N)NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclo(-RGDfK)

Solubility

Soluble to 1mg/ml in water

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References for Cyclo(-RGDfK)

References are publications that support the biological activity of the product.

Gamage Comparison of cRGDfK peptide probes with appended shielded heptamethine cyanine dye (s775z) for near infrared fluorescence imaging of cancer. ACS Omega 2021 PMID: 34778684
Lambshead Long-term maintenance of human pluripotent stem cells on cRGDfK-presenting synthetic surfaces. Sci.Rep. 2018 PMID: 29335618
Kapp A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. Sci Rep 2017 PMID: 28074920
Yu Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death Dis. 2017 PMID: 28383553