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19 results for "Compounds for ESC/iPSC Proliferation and Renewal" in Products

Compounds for ESC/iPSC Proliferation and Renewal Products

Embryonic stem cells (ESCs) are found in the inner cell mass of blastocysts. They are considered immortal as they have an unlimited capacity for self-renewal in an undifferentiated state. ESCs have the ability to differentiate into cells from all three germ layers (endoderm, mesoderm and ectoderm).

Embryonic stem cells (ESCs) are pluripotent cells and differentiation is tightly controlled by growth factor, cytokines and Epigenetic processes such as DNA methylation and chromatin remodeling. ...

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Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component

Alternate Names: y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor
Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥98% (HPLC)
ROCK inhibition by Y-27632 and immunostaining of skeletal myogenic differentiation of MESP1+ mesoderm,
(8)

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99% (HPLC)
dopaminergic neurons derived from hiPSCs using SB 431542
(2)

Y-27632 synthesized to cGMP guidelines

Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥99%
Y-27632 synthesized to cGMP guidelines

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98% (HPLC)
Adult Stem Cell-derived Liver Organoids
(6)

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity: ≥99% (HPLC)
Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Sterile-filtered 10 mM solution of Y-27632, selective ROCK inhibitor, pre-dissolved in water

Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity: ≥97% (HPLC)
vial of Y-27632 in solution
(2)

Cell culture supplement for improving stem cell survival

cept-cocktail-product-image

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

Chemical Name: (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis

MEK inhibitor

Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
MEK inhibitor

Potent pan-caspase inhibitor

Alternate Names: IDN-6556,PF-03491390
Chemical Name: N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide
Purity: ≥98% (HPLC)
Potent pan-caspase inhibitor

PORCN inhibitor; inhibits Wnt processing and secretion

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity: ≥98% (HPLC)
iPSC-derived heart organoids differentiated with IWP 2 and CHIR 99021
(2)

Potent AMPK activator

Chemical Name: 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Purity: ≥98% (HPLC)
Potent AMPK activator

Enhances survival of human ESCs following enzymatic dissociation

Chemical Name: N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
Purity: ≥98% (HPLC)
Enhances survival of human ESCs following enzymatic dissociation

Potent, selective GSK-3 inhibitor

Chemical Name: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Potent, selective GSK-3 inhibitor

Potent GSK-3 inhibitor; also inhibits cdks

Alternate Names: 6BIO
Chemical Name: (2'Z,3'E)-6-Bromoindirubin-3'-oxime
Purity: ≥98% (HPLC)
Potent GSK-3 inhibitor; also inhibits cdks

Heparin sulfate antagonist

Chemical Name: N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride
Purity: ≥98% (HPLC)
Heparin sulfate antagonist

Potent and selective Lck and Src inhibitor; also inhibits SIK

Alternate Names: KIN112
Chemical Name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
Purity: ≥98% (HPLC)
Potent and selective Lck and Src inhibitor; also inhibits SIK

Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development

Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Purity: ≥95% (HPLC)
Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development

Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds

Purity: ≥95% (HPLC)
Potent integrin inhibitor (αVβ3/αVβ5); also improves stem cell attachment in 3D cell culture scaffolds
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