WH-4-023

Name: WH-4-023
Brand: Tocris Bioscience
SKU: 5413

Tocris Bioscience, part of Bio-Techne | Catalog # 5413

Citations (11)

COA / SDS

Potent and selective Lck and Src inhibitor; also inhibits SIK

Key Product Details

Description:	Potent and selective Lck and Src inhibitor; also inhibits SIK
Alternative Names:	KIN112
Chemical Name:	2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	568.67

View Full Technical Details for WH-4-023

Technical Data
Citations

Biological Activity for WH-4-023

WH-4-023 is a potent and selective Lck and Src inhibitor (IC₅₀ values are 2 and 6 nM respectively). Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC₅₀ values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hESCs in combination with PD 0325901, CHIR 99021 and SB 590885.

Compound Libraries for WH-4-023

WH-4-023 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of WH-4-023 is reviewed on the chemical probes website.

Technical Data for WH-4-023

M. Wt	568.67
Formula	C₃₂H₃₆N₆O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	837422-57-8
PubChem ID	11844351
InChi Key	NBTNHSGBRGTFJS-UHFFFAOYSA-N
Smiles	O=C(OC5=C(C)C=CC=C5C)N(C4=CC=C(OC)C=C4OC)C1=NC(NC(C=C3)=CC=C3N2CCN(C)CC2)=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WH-4-023

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	56.87	100

Preparing Stock Solutions for WH-4-023

The following data is based on the product molecular weight 568.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.79 mL	17.58 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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References for WH-4-023

References are publications that support the biological activity of the product.

Clark Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 23033494
Martin Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J.Med.Chem. 2006 PMID: 16884310
Theunissen Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell 2014 PMID: 25090446