19 results for "Src Family Kinase Inhibitors" in Products
Src Family Kinase Inhibitors Products
Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure with a high degree of homology in the SH1 (catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association) domains.
c-Src, Fyn and Yes are ubiquitously expressed, although high ...
Potent, selective Src family kinase inhibitor
| Chemical Name: | 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
Potent, selective Src family kinase inhibitor
| Chemical Name: | 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable
| Chemical Name: | 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide |
| Purity: | ≥95% (HPLC) |
Src family kinase inhibitor; also inhibits c-Abl
| Alternate Names: | 1-NA-PP 1 |
| Chemical Name: | 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
Inhibitor of Src family kinases
| Chemical Name: | 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride |
| Purity: | ≥98% (HPLC) |
Dual site Src kinase inhibitor
| Chemical Name: | 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine |
| Purity: | ≥98% (HPLC) |
Potent and selective Lck and Src inhibitor; also inhibits SIK
| Alternate Names: | KIN112 |
| Chemical Name: | 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate |
| Purity: | ≥98% (HPLC) |
Potent and selective c-Src inhibitor
| Chemical Name: | 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
Src tyrosine kinase inhibitor
| Chemical Name: | N-(2-Chloro-5-methoxyphenyl)-6-methoxy |
| Purity: | ≥98% (HPLC) |
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable
| Alternate Names: | AZD 0530 |
| Chemical Name: | N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine |
| Purity: | ≥98% (HPLC) |
Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable
| Chemical Name: | 3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
| Chemical Name: | 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride |
| Purity: | ≥98% (HPLC) |
Highly potent pan-Src/Bcr-Abl inhibitor
| Alternate Names: | BMS-354825 |
| Chemical Name: | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide |
| Purity: | ≥98% (HPLC) |
Dual Src-Abl inhibitor; antiproliferative
| Alternate Names: | SKI-606 |
| Chemical Name: | 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Purity: | ≥98% |
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
| Chemical Name: | 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride |
| Purity: | ≥98% (HPLC) |
UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
| Chemical Name: | Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride |
| Purity: | ≥98% (HPLC) |
Negative control for PP 2 (Cat. No. 1407)
| Chemical Name: | 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
Potent Lck inhibitor
| Chemical Name: | 6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one |
| Purity: | ≥98% (HPLC) |
Potent and selective breast tumor kinase (Brk) inhibitor
| Chemical Name: | 3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol |
| Purity: | ≥98% (HPLC) |
