LCB 03-0110 dihydrochloride

Name: LCB 03-0110 dihydrochloride
Brand: Tocris Bioscience
SKU: 5592
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 5592

Citations (2)

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
Chemical Name:	3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	490.45

View Full Technical Details for LCB 03-0110 dihydrochloride

Biological Activity for LCB 03-0110 dihydrochloride

LCB 03-0110 dihydrochloride is a potent c-Src kinase inhibitor (IC₅₀ = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.

Compound Libraries for LCB 03-0110 dihydrochloride

LCB 03-0110 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for LCB 03-0110 dihydrochloride

M. Wt	490.45
Formula	C₂₄H₂₃N₃O₂S.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1962928-28-4
PubChem ID	121513872
InChi Key	OEWGAUGZPPUIPF-UHFFFAOYSA-N
Smiles	OC1=CC=CC(NC2=CC=NC3=C2SC(C4=CC=CC(CN5CCOCC5)=C4)=C3)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LCB 03-0110 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	49.05	100
	DMSO	49.05	100

Preparing Stock Solutions for LCB 03-0110 dihydrochloride

The following data is based on the product molecular weight 490.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.19 mL	20.39 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for LCB 03-0110 dihydrochloride

References are publications that support the biological activity of the product.

Sun LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J.Pharmacol.Exp.Ther. 2012 PMID: 22128347

Citations for LCB 03-0110 dihydrochloride (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for LCB 03-0110 dihydrochloride include:

Fowler et al. (2019) Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration. Drugs R D. 19:149
PMID: 30919310
Mogami (2018) Collagen Type 1 accelerates healing of ruptured fetal membranes. Sci Rep. 8(1):696
PMID: 29330408

There are no citations that match your criteria.

Showing 1 - 2 of 2 citations Showing All

Customer Reviews for LCB 03-0110 dihydrochloride (1)

4 out of 5

1 customer rating

5 stars

4 stars

100%

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

Collagen type 1 activated collagen receptor discoidin domain receptor

Name: Anonymous

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: 3D Culture Matrix

10 μg/ml treat 24h and 48h

PMID: 29330408

There are no reviews that match your criteria.

Showing 1 - 1 of 1 review Showing All

Product Documents for LCB 03-0110 dihydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.