PP 3
Tocris Bioscience, part of Bio-Techne | Catalog # 2794
Negative control for PP 2 (Cat. No. 1407)
Key Product Details
Description
Negative control for PP 2 (Cat. No. 1407)
Product Description
PP 3 is a negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC50 = 2.7 μM).Active Analog also available.
Product Specifications
Molecular Weight
211.22
Formula
C11H9N5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
5334-30-5
PubChem ID
4879
InChI Key
KKDPIZPUTYIBFX-UHFFFAOYSA-N
SMILES
NC1=NC=NC2=C1C=NN2C3=CC=CC=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.12 | 100 | |
| Ethanol | 5.28 | 25 |
Preparing Stock Solutions
for PP 3
The following data is based on the product molecular weight 211.22
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.73 mL | 23.67 mL | 47.34 mL |
| 5 mM | 0.95 mL | 4.73 mL | 9.47 mL |
| 10 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.95 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hou PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 2007 PMID: 17556100
- Traxler Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 1997 PMID: 9357527
Product Specific Notices for PP 3
For research use only
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