PP 3

Name: PP 3
Brand: Tocris Bioscience
SKU: 2794

Catalog # 2794 | Tocris Bioscience a Bio-Techne Brand

Citations (7)

COA / SDS

Negative control for PP 2 (Cat. No. 1407)

Key Product Details

Description:	Negative control for PP 2 (Cat. No. 1407)
Chemical Name:	1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	211.22

View Full Technical Details for PP 3

Technical Data
Citations (7) / Reviews

Biological Activity for PP 3

PP 3 is a negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC₅₀ = 2.7 μM).

Active Analog also available.

Compound Libraries for PP 3

PP 3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PP 3

M. Wt	211.22
Formula	C₁₁H₉N₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	5334-30-5
PubChem ID	4879
InChi Key	KKDPIZPUTYIBFX-UHFFFAOYSA-N
Smiles	NC1=NC=NC2=C1C=NN2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PP 3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	21.12	100
	ethanol	5.28	25

Preparing Stock Solutions for PP 3

The following data is based on the product molecular weight 211.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.73 mL	23.67 mL	47.34 mL
5 mM	0.95 mL	4.73 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.73 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

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Reconstitution Calculator

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References for PP 3

References are publications that support the biological activity of the product.

Hou PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 2007 PMID: 17556100
Traxler Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 1997 PMID: 9357527

Citations for PP 3 (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for PP 3 include:

Hass et al. (2017) Mathematical model of early Reelin-induced Src family kinase-mediated signaling. PLoS One. 12:e0186927
PMID: 29049379
Li et al. (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest. 126:389
PMID: 26657863
Vijayakumar et al. (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Neural Regen Res. 128:251
PMID: 25413351
Kubota et al. (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One. 9:e106316
PMID: 25181481
Rosas et al. (2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Cell. 9:2164
PMID: 25657738
Kupferman et al. (2014) Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. J Neuroimmune Pharmacol. 158:1335
PMID: 25201528
Chen et al. (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci. 39:1439
PMID: 24611998

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