Src I1

Name: Src I1
Brand: Tocris Bioscience
SKU: 3642

Tocris Bioscience a Bio-Techne Brand

Catalog # 3642

Citations (2)

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Key Product Details

Description:	Dual site Src kinase inhibitor
Chemical Name:	6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Purity:	≥99% (HPLC)
Molecular Weight:	373.4

View Full Technical Details for Src I1

Biological Activity for Src I1

Src I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC₅₀ values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC₅₀ values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.

Compound Libraries for Src I1

Src I1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Src I1

M. Wt	373.4
Formula	C₂₂H₁₉N₃O₃
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	179248-59-0
PubChem ID	1474853
InChi Key	DMWVGXGXHPOEPT-UHFFFAOYSA-N
Smiles	COC(C(OC)=C3)=CC1=C3N=CN=C1NC2=CC=C(OC4=CC=CC=C4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Src I1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.34	100

Preparing Stock Solutions for Src I1

The following data is based on the product molecular weight 373.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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Reconstitution Calculator

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References for Src I1

References are publications that support the biological activity of the product.

Bain The selectivity of protein kinase inhibitors: a further update. Biochem.J. 2007 PMID: 17850214
Tian Structural determinants for potent, selective dual site inhibition of human pp60^c-src by 4-anilinoquinazolines. Biochem. 2001 PMID: 11401553

Citations for Src I1 (2)

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Citations are publications that use Bio-Techne products. Selected citations for Src I1 include:

Zhang et al. (2019) CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol. 20:7
PMID: 30674283
Leung et al. (2015) PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. J Immunol. 194:2930
PMID: 25687758

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