1-Naphthyl PP1
Tocris Bioscience, part of Bio-Techne | Catalog # 3063
Src family kinase inhibitor; also inhibits c-Abl
Key Product Details
Description
Src family kinase inhibitor; also inhibits c-Abl
Alternative Names
1-NA-PP 1
Product Description
1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).Product Specifications
Molecular Weight
317.39
Formula
C19H19N5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
221243-82-9
PubChem ID
4877
InChI Key
XSHQBIXMLULFEV-UHFFFAOYSA-N
SMILES
NC1=NC=NC2=C1C(C3=C4C(C=CC=C4)=CC=C3)=NN2C(C)(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.35 | 20 |
Preparing Stock Solutions
for 1-Naphthyl PP1
The following data is based on the product molecular weight 317.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.75 mL | 78.77 mL | 157.53 mL |
| 1 mM | 3.15 mL | 15.75 mL | 31.51 mL |
| 2 mM | 1.58 mL | 7.88 mL | 15.75 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bishop Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc.
- Bishop A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000 PMID: 11014197
Product Specific Notices for 1-Naphthyl PP1
For research use only
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