1-Naphthyl PP1

Name: 1-Naphthyl PP1
Brand: Tocris Bioscience
SKU: 3063
Price: 332 USD

Catalog # 3063 | Tocris Bioscience a Bio-Techne Brand

Citations (6)

COA / SDS

Src family kinase inhibitor; also inhibits c-Abl

Key Product Details

Description:	Src family kinase inhibitor; also inhibits c-Abl
Alternative Names:	1-NA-PP 1
Chemical Name:	1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥99% (HPLC)
Molecular Weight:	317.39

View Full Technical Details for 1-Naphthyl PP1

Biological Activity for 1-Naphthyl PP1

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC₅₀ values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC₅₀ values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Compound Libraries for 1-Naphthyl PP1

1-Naphthyl PP1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for 1-Naphthyl PP1

M. Wt	317.39
Formula	C₁₉H₁₉N₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	221243-82-9
PubChem ID	4877
InChi Key	XSHQBIXMLULFEV-UHFFFAOYSA-N
Smiles	NC1=NC=NC2=C1C(C3=C4C(C=CC=C4)=CC=C3)=NN2C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1-Naphthyl PP1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.35	20

Preparing Stock Solutions for 1-Naphthyl PP1

The following data is based on the product molecular weight 317.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.75 mL	78.77 mL	157.53 mL
1 mM	3.15 mL	15.75 mL	31.51 mL
2 mM	1.58 mL	7.88 mL	15.75 mL
10 mM	0.32 mL	1.58 mL	3.15 mL

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References for 1-Naphthyl PP1

References are publications that support the biological activity of the product.

Bishop A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000 PMID: 11014197
Bishop Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc.

Citations for 1-Naphthyl PP1 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for 1-Naphthyl PP1 include:

O'Neill et al. (2016) Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol. 215:217
PMID: 27810913
Chen et al. (2015) Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol. 13:e1002329
PMID: 26682552
Meyer et al. (2015) Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae. Genes Dev. 26:2986
PMID: 26157162
Suhandynata et al. (2014) A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture. G3 (Bethesda). 4:2125
PMID: 25168012
Kim et al. (2013) Dual mechanisms prevent premature chromosome segregation during meiosis. Cell Death Dis. 27:2139
PMID: 24115770
Lo and Hollingsworth (2011) Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1. Methods Mol Biol. 745:135
PMID: 21660693

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