KB SRC 4
Tocris Bioscience, part of Bio-Techne | Catalog # 4660
Potent and selective c-Src inhibitor
Key Product Details
Description
Potent and selective c-Src inhibitor
Product Description
KB SRC 4 is a potent and selective c-Src inhibitor (Ki = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (Kd values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.Product Specifications
Molecular Weight
555.03
Formula
C32H23ClN8
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
1380088-03-8
PubChem ID
73349077
InChI Key
UHIZYQVRKSWIFO-UHFFFAOYSA-N
SMILES
NC1=C2C(N(C4=CC=CC(C5=CN=NN5CC6=CC(C7=CC=CC=C7)=CC=C6)=C4)N=C2C3=CC=C(Cl)C=C3)=NC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.1 | 20 |
Preparing Stock Solutions
for KB SRC 4
The following data is based on the product molecular weight 555.03
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.01 mL | 45.04 mL | 90.09 mL |
| 1 mM | 1.80 mL | 9.01 mL | 18.02 mL |
| 2 mM | 0.90 mL | 4.50 mL | 9.01 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brandvold Development of a highly selective c-Src kinase inhibitor. ACS Chem.Biol. 2012 PMID: 22594480
Product Specific Notices for KB SRC 4
For research use only
Loading...
Loading...