KB SRC 4

Name: KB SRC 4
Brand: Tocris Bioscience
SKU: 4660

Tocris Bioscience a Bio-Techne Brand

Catalog # 4660

Citations (2)

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Key Product Details

Description:	Potent and selective c-Src inhibitor
Chemical Name:	1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	555.03

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Biological Activity for KB SRC 4

KB SRC 4 is a potent and selective c-Src inhibitor (K_i = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (K_d values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.

Compound Libraries for KB SRC 4

KB SRC 4 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for KB SRC 4

M. Wt	555.03
Formula	C₃₂H₂₃ClN₈
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1380088-03-8
PubChem ID	73349077
InChi Key	UHIZYQVRKSWIFO-UHFFFAOYSA-N
Smiles	NC1=C2C(N(C4=CC=CC(C5=CN=NN5CC6=CC(C7=CC=CC=C7)=CC=C6)=C4)N=C2C3=CC=C(Cl)C=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KB SRC 4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.1	20

Preparing Stock Solutions for KB SRC 4

The following data is based on the product molecular weight 555.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.01 mL	45.04 mL	90.09 mL
1 mM	1.80 mL	9.01 mL	18.02 mL
2 mM	0.90 mL	4.50 mL	9.01 mL
10 mM	0.18 mL	0.90 mL	1.80 mL

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References for KB SRC 4

References are publications that support the biological activity of the product.

Brandvold Development of a highly selective c-Src kinase inhibitor. ACS Chem.Biol. 2012 PMID: 22594480

Citations for KB SRC 4 (2)

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Citations are publications that use Bio-Techne products. Selected citations for KB SRC 4 include:

Carmona et al. (2016) Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Oncogene. 35:5155
PMID: 26996666
Kim et al. (2014) An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol. 34:4368
PMID: 25312644

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