Tilfrinib

Name: Tilfrinib
Brand: Tocris Bioscience
SKU: 5579

Tocris Bioscience a Bio-Techne Brand

Catalog # 5579

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Key Product Details

Description:	Potent and selective breast tumor kinase (Brk) inhibitor
Chemical Name:	3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
Purity:	≥98% (HPLC)
Molecular Weight:	275.3

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Biological Activity for Tilfrinib

Tilfrinib is a potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC₅₀ = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.

Licensing Information

Sold under license from Martin-Luther-Universität-Halle-Wittenburg

Compound Libraries for Tilfrinib

Tilfrinib is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Tilfrinib

M. Wt	275.3
Formula	C₁₇H₁₃N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1600515-49-8
PubChem ID	76332983
InChi Key	RXPZOSHFGJWSLQ-UHFFFAOYSA-N
Smiles	OC1=CC=CC(NC2=C3C(NC4=CC=CC=C43)=NC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tilfrinib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.53	100

Preparing Stock Solutions for Tilfrinib

The following data is based on the product molecular weight 275.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.63 mL	18.16 mL	36.32 mL
5 mM	0.73 mL	3.63 mL	7.26 mL
10 mM	0.36 mL	1.82 mL	3.63 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

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Reconstitution Calculator

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References for Tilfrinib

References are publications that support the biological activity of the product.

Mahmoud Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg.Med.Chem.Lett. 2014 PMID: 24650640

Citations for Tilfrinib

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