AZM 475271

Name: AZM 475271
Brand: Tocris Bioscience
SKU: 3963

Tocris Bioscience a Bio-Techne Brand

Catalog # 3963

Citations (4)

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Key Product Details

Description:	Src tyrosine kinase inhibitor
Chemical Name:	N-(2-Chloro-5-methoxyphenyl)-6-methoxy
Purity:	≥99% (HPLC)
Molecular Weight:	442.94

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Biological Activity for AZM 475271

AZM 475271 is a src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AZM 475271

AZM 475271 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZM 475271

M. Wt	442.94
Formula	C₂₃H₂₇ClN₄O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	476159-98-5
PubChem ID	5330175
InChi Key	WPOXAFXHRJYEIC-UHFFFAOYSA-N
Smiles	ClC1=CC=C(OC)C=C1NC3=NC=NC2=CC(OCC4CCN(C)CC4)=C(OC)C=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZM 475271

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.29	100

Preparing Stock Solutions for AZM 475271

The following data is based on the product molecular weight 442.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.29 mL	22.58 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for AZM 475271

References are publications that support the biological activity of the product.

Summy AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol.Cancer Ther. 2005 PMID: 16373705
Yezhelyev Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin.Cancer Res. 2004 PMID: 15585638

Citations for AZM 475271 (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for AZM 475271 include:

Gautam et al. (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer. 15:75
PMID: 27871326
Wang et al. (2016) Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2. Br J Pharmacol. 173:3342
PMID: 27638545
Thakur et al. (2015) Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep. 5:10194
PMID: 25973915
Leoni et al. (2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest. 123:443
PMID: 23241962

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