Squarunkin A hydrochloride

Name: Squarunkin A hydrochloride
Brand: Tocris Bioscience
SKU: 6364

Tocris Bioscience a Bio-Techne Brand

Catalog # 6364

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Key Product Details

Description:	UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
Chemical Name:	Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	560.01

View Full Technical Details for Squarunkin A hydrochloride

Biological Activity for Squarunkin A hydrochloride

Squarunkin A hydrochloride is a potent inhibitor of UNC119 chaperone protein-cargo interaction (IC₅₀ = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.

Compound Libraries for Squarunkin A hydrochloride

Squarunkin A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Squarunkin A hydrochloride

M. Wt	560.01
Formula	C₂₅H₃₂F₃N₅O₄.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2253744-55-5
Smiles	CCOC(N1CCC(NC2=C(C(C2=O)=O)NCCN3CCN(C4=CC(C(F)(F)F)=CC=C4)CC3)CC1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Squarunkin A hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28	50

Preparing Stock Solutions for Squarunkin A hydrochloride

The following data is based on the product molecular weight 560.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.57 mL	17.86 mL	35.71 mL
2.5 mM	0.71 mL	3.57 mL	7.14 mL
5 mM	0.36 mL	1.79 mL	3.57 mL
25 mM	0.07 mL	0.36 mL	0.71 mL

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References for Squarunkin A hydrochloride

References are publications that support the biological activity of the product.

Mejuch Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 2017 PMID: 28471079

Citations for Squarunkin A hydrochloride

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