Squarunkin A hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6364
UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
Key Product Details
Description
UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
Product Description
Squarunkin A hydrochloride is a potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.Product Specifications
Molecular Weight
560.01
Formula
C25H32F3N5O4.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride
CAS Number
2253744-55-5]
SMILES
CCOC(N1CCC(NC2=C(C(C2=O)=O)NCCN3CCN(C4=CC(C(F)(F)F)=CC=C4)CC3)CC1)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28 | 50 |
Preparing Stock Solutions
for Squarunkin A hydrochloride
The following data is based on the product molecular weight 560.01
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.57 mL | 17.86 mL | 35.71 mL |
| 2.5 mM | 0.71 mL | 3.57 mL | 7.14 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.57 mL |
| 25 mM | 0.07 mL | 0.36 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mejuch Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 2017 PMID: 28471079
Product Specific Notices for Squarunkin A hydrochloride
For research use only
Loading...
Loading...