TL 0259
Tocris Bioscience, part of Bio-Techne | Catalog # 6981
Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable
Key Product Details
Description
Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable
Product Description
TL 0259 is a selective and highly potent Fgr and Lyn inhibitor (IC50 values are 0.03 and 0.1 nM, respectively). Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases. Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro. Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts. Orally bioavailable.Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
682.56
Formula
C32H34F3N5O4.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride
CAS Number
2415263-06-6
InChI Key
AMHWQBGAKJESFB-UHFFFAOYSA-N
SMILES
CCN1CCN(CC1)CC2=C(C(F)(F)F)C=C(C=C2)NC(C3=CC=C(C(OC4=NC=NC5=C4C=C(C(OC)=C5)OC)=C3)C)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.13 | 50 |
Preparing Stock Solutions
for TL 0259
The following data is based on the product molecular weight 682.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.93 mL | 14.65 mL | 29.30 mL |
| 2.5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
| 5 mM | 0.29 mL | 1.47 mL | 2.93 mL |
| 25 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Weir Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo. ACS Chem.Biol. 2018 PMID: 29763550
Product Specific Notices for TL 0259
For research use only
Loading...
Loading...