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PD 0325901

MEK Inhibitors Small Molecule
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4192/50
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Key Product Details

Description: Potent inhibitor of MEK1/2
Alternative Names: PD325901
Chemical Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Purity: ≥99% (HPLC)
Molecular Weight: 482.19

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Citations (21)

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  • ESC culture
    Name: Xiaoyu Zhang
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: ESC
    In vitro cell culture addition. The image shows the morphology of ESC colonies after conversion by using the treatment condition. This condition supported the conversion and long-term maintenance of dome-shaped ESCs from primed ESCs.
    PD 0325901 Serum 4192
  • All iPSC lines and R1 mouse ES cells were maintained on feeders in KO-DMEM (Invitrogen) with 3 mM CHIR99021, and 1 mM PD0325901.
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: ipsc
    All iPSC lines and R1 mouse ES cells were maintained on feeders in KO-DMEM (Invitrogen) with 3 mM CHIR99021, and 1 mM PD0325901.
    PD 0325901 Serum 4192
  • 2i conditions for mES cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Used to grow mES cells in 2i conidtions. The cells grew well and I did QPCR on isolated RNA
    PD 0325901 Serum 4192
  • Mmaintenance of naive pluripotency in 2i
    Name: Megha PB
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: E14TG2a
    Mouse ES cells in 2i remain to be in the naive pluripotent state while cells in -2i for 48 hours exit naive pluripotency
    PD 0325901 Serum 4192
  • Great inhibitor for ERK signaling
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary mouse lung endothelial cells
    Primary lung endothelial cells were pretreated with various concentrations of PD 0325901 for 30 minutes prior to the treatment of IL1b (1ng/ml).
    24 hours later, cell was lyzed and analyzed by western blot. Lane 1: PBS controlLane 2: + PD 0326901 100nMLane 3: + PD 0326901 10nM
    PD 0325901 Serum 4192

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