55 results for "Autophagy-related Compounds Small Molecules and Peptides" in Products

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Autophagy-related Compounds Small Molecules and Peptides

Dorsomorphin dihydrochloride
Catalog #: 3093
(3)
Citations (321)
Product Documents
Images (1)

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Alternate Names:
Compound C,BML-275
Chemical Name:
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Purity:
≥98%
Potent AMPK inhibitor; also BMP type I receptor inhibitor
Catalog #
Availability
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3093/10
3093/50
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LY 294002 hydrochloride
Catalog #: 1130
(7)
Citations (111)
Product Documents
Images (1)

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity:
≥99%
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
Catalog #
Availability
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1130/25
1130/5
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Torin 1
Catalog #: 4247
(2)
Citations (651)
Product Documents
Images (1)

Potent and selective mTOR inhibitor

Chemical Name:
1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity:
≥98%
Potent and selective mTOR inhibitor
Catalog #
Availability
Size / Price
Qty
4247/50
4247/10
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Bafilomycin A1
Catalog #: 1334
(3)
Citations (296)
Product Documents
Images (1)

H+-ATPase (vacuolar) inhibitor

Chemical Name:
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Purity:
≥95%
H+-ATPase (vacuolar) inhibitor
Catalog #
Availability
Size / Price
Qty
1334/100U
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Thapsigargin
Catalog #: 1138
(7)
Citations (466)
Product Documents
Images (1)

Potent inhibitor of SERCA ATPase

Chemical Name:
(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
Purity:
≥97%
Potent inhibitor of SERCA ATPase
Catalog #
Availability
Size / Price
Qty
1138/1
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Dexamethasone
Catalog #: 1126
(2)
Citations (115)
Product Documents
Images (1)

Anti-inflammatory glucocorticoid

Chemical Name:
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Purity:
≥98%
Anti-inflammatory glucocorticoid
Catalog #
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1126/100
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Taxol
Catalog #: 1097
(2)
Citations (130)
Product Documents
Images (1)

Promotes assembly and inhibits disassembly of microtubules

Alternate Names:
Paclitaxel
Chemical Name:
[2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity:
≥98%
Promotes assembly and inhibits disassembly of microtubules
Catalog #
Availability
Size / Price
Qty
1097/50
1097/10
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Rapamycin
Catalog #: 1292
(3)
Citations (386)
Product Documents
Images (1)

mTOR inhibitor; immunosuppressant

Chemical Name:
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Purity:
≥98%
mTOR inhibitor; immunosuppressant
Catalog #
Availability
Size / Price
Qty
1292/1
Bulk Order

Pepstatin A
Catalog #: 1190
(5)
Citations (48)
Product Documents
Images (1)

Selective and high affinity cathepsin D inhibitor

Purity:
≥95%
Selective and high affinity cathepsin D inhibitor
Catalog #
Availability
Size / Price
Qty
1190/10
Bulk Order

Wortmannin
Catalog #: 1232
(2)
Citations (300)
Product Documents
Images (1)

Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1

Alternate Names:
SL-2052
Chemical Name:
(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
Purity:
≥98%
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
Catalog #
Availability
Size / Price
Qty
1232/5
1232/1
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Everolimus
Catalog #: 6188
Citations (16)
Product Documents
Images (1)

mTOR inhibitor; Immunosuppressant

Alternate Names:
RAD001
Chemical Name:
42-O-(2-Hydroxyethyl)rapamycin
Purity:
≥98%
mTOR inhibitor; Immunosuppressant
Catalog #
Availability
Size / Price
Qty
6188/10
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GF 109203X
Catalog #: 0741
(1)
Citations (311)
Product Documents
Images (1)

Protein kinase C inhibitor

Alternate Names:
Gö 6850,Bisindolylmaleimide I
Chemical Name:
2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
Purity:
≥98%
Protein kinase C inhibitor
Catalog #
Availability
Size / Price
Qty
0741/1
0741/10
Bulk Order

Metformin hydrochloride
Catalog #: 2864
(3)
Citations (38)
Product Documents
Images (1)

Activator of LKB1/AMPK; antidiabetic agent

Chemical Name:
N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Activator of LKB1/AMPK; antidiabetic agent
Catalog #
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Size / Price
Qty
2864/100
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Pifithrin-α hydrobromide
Catalog #: 1267
(3)
Citations (14)
Product Documents
Images (1)

p53 inhibitor. Also aryl hydrocarbon receptor agonist

Chemical Name:
1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
p53 inhibitor. Also aryl hydrocarbon receptor agonist
Catalog #
Availability
Size / Price
Qty
1267/10
1267/50
Bulk Order

Niclosamide
Catalog #: 4079
Citations (10)
Product Documents
Images (1)

STAT3 inhibitor; also inhibits mTORC1 signaling

Chemical Name:
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Purity:
≥98%
STAT3 inhibitor; also inhibits mTORC1 signaling
Catalog #
Availability
Size / Price
Qty
4079/50
Bulk Order

Carbamazepine
Catalog #: 4098
(1)
Citations (23)
Product Documents
Images (1)

Inhibitor of neuronal NaV channels; anticonvulsant

Alternate Names:
CBZ
Chemical Name:
5H-Dibenz[b,f]azepine-5-carboxamide
Purity:
≥98%
Inhibitor of neuronal NaV channels; anticonvulsant
Catalog #
Availability
Size / Price
Qty
4098/50
Bulk Order

Valproic acid, sodium salt
Catalog #: 2815
(2)
Citations (27)
Product Documents
Images (1)

Histone deacetylase inhibitor

Alternate Names:
VPA,Sodium Valproate
Chemical Name:
Sodium 2-propylpentanoate
Histone deacetylase inhibitor
Catalog #
Availability
Size / Price
Qty
2815/100
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A 769662
Catalog #: 3336
Citations (123)
Product Documents
Images (1)

Potent AMPK activator

Chemical Name:
6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Purity:
≥98%
Potent AMPK activator
Catalog #
Availability
Size / Price
Qty
3336/10
3336/50
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Tunicamycin
Catalog #: 3516
(4)
Citations (112)
Product Documents
Images (1)

Antibiotic; GlcNAc phosphotransferase inhibitor

Chemical Name:
Tunicamycin from Streptomyces sp.
Purity:
≥98%
Antibiotic; GlcNAc phosphotransferase inhibitor
Catalog #
Availability
Size / Price
Qty
3516/10
Bulk Order

Chloroquine diphosphate
Catalog #: 4109
(1)
Citations (32)
Product Documents
Images (1)

Antimalarial; inhibits apoptosis and autophagy

Chemical Name:
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Purity:
≥98%
Antimalarial; inhibits apoptosis and autophagy
Catalog #
Availability
Size / Price
Qty
4109/50
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NF 449
Catalog #: 1391
Citations (114)
Product Documents
Images (1)

Highly selective P2X1 antagonist

Chemical Name:
4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid, octasodium salt
Purity:
≥90%
Highly selective P2X1 antagonist
Catalog #
Availability
Size / Price
Qty
1391/10
1391/50
Bulk Order

Brefeldin A
Catalog #: 1231
(1)
Citations (98)
Product Documents
Images (1)

Disrupts protein translocation to Golgi

Chemical Name:
1,6,7,8,9,11aβ,12,13,14,14aα-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
Purity:
≥98%
Disrupts protein translocation to Golgi
Catalog #
Availability
Size / Price
Qty
1231/5
Bulk Order

Temozolomide
Catalog #: 2706
(1)
Citations (37)
Product Documents
Images (1)

DNA-methylating antitumor agent

Alternate Names:
NSC 362856,CCRG 81045
Chemical Name:
3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
Purity:
≥98%
DNA-methylating antitumor agent
Catalog #
Availability
Size / Price
Qty
2706/10
2706/50
Bulk Order

PI 103 hydrochloride
Catalog #: 2930
Citations (32)
Product Documents
Images (1)

Inhibitor of PI 3-kinase, mTOR and DNA-PK

Chemical Name:
3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride
Purity:
≥97%
Inhibitor of PI 3-kinase, mTOR and DNA-PK
Catalog #
Availability
Size / Price
Qty
2930/1
2930/10
Bulk Order

Rapamycin
Catalog #: 1292
(3)
Citations (386)
Product Documents
Images (1)

mTOR inhibitor; immunosuppressant

Chemical Name:
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Purity:
≥98%
mTOR inhibitor; immunosuppressant
Catalog #
Availability
Size / Price
Qty
1292/1
Bulk Order
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