Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC₅₀ = 5.8 nM).

Product Specifications

Molecular Weight

428.44

Formula

C₂₃H₂₄O₈

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione

CAS Number

19545-26-7

PubChem ID

3003565

InChI Key

QDLHCMPXEPAAMD-ZGSWIPFCSA-N

SMILES

O=C(C4=CO5)O[C@H](COC)[C@@]1(C)C4=C5C(C2=C1[C@H](OC(C)=O)C[C@@]3(C)C2CCC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.42	50

Preparing Stock Solutions for Wortmannin

The following data is based on the product molecular weight 428.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.67 mL	23.34 mL	46.68 mL
2.5 mM	0.93 mL	4.67 mL	9.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
25 mM	0.09 mL	0.47 mL	0.93 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Schultz In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor wortmannin. Anticancer Res. 1995 PMID: 7653991
Liu Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase. Chem.Biol. 2005 PMID: 15664519
Powis Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 1994 PMID: 8162590
Arcaro and Wymann Wortmannin is a potent phophatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem.J. 1993 PMID: 8257416

Wortmannin

Tocris Bioscience, part of Bio-Techne | Catalog # 1232

Key Product Details

Description

Alternative Names

View all PI 3-Kinase Inhibitors »

Product Description