Dexamethasone

Name: Dexamethasone
Brand: Tocris Bioscience
SKU: 1126
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1126

Citations (8)

(1)

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Key Product Details

Description:	Anti-inflammatory glucocorticoid
Chemical Name:	(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Purity:	≥98% (HPLC)
Molecular Weight:	392.47

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Biological Activity for Dexamethasone

Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries for Dexamethasone

Dexamethasone is also offered as part of the Tocriscreen Antiviral Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Dexamethasone

M. Wt	392.47
Formula	C₂₂H₂₉FO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	50-02-2
PubChem ID	9830630
InChi Key	UREBDLICKHMUKA-WNYCSEIESA-N
Smiles	O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dexamethasone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.25	100

Preparing Stock Solutions for Dexamethasone

The following data is based on the product molecular weight 392.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for Dexamethasone

References are publications that support the biological activity of the product.

Huch Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 2015 PMID: 25533785
Deng The effect of dexamethasone on lentiviral vector infection is associated with importin α. Biomed.Rep. 2014 PMID: 24649085
Sittichokechaiwut Short bouts of mechanical loading are as effective as dexameth. at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 2010 PMID: 20648425
Laane Cell death induced by dexameth. in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 2009 PMID: 19390558
Seregin Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Mol.Ther. 2009 PMID: 19174760
Matasic Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 1999 PMID: 10614771
Teixeira Effects of dexameth. and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 1996 PMID: 8735633

Citations for Dexamethasone (8)

Showing 1 - 8 of 8 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Dexamethasone include:

Segal et al. (2019) Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun. 10:3350
PMID: 31350390
Ibrahim et al. (2018) Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci. 12:453
PMID: 30524245
Peng et al. (2018) Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Cell. 175:1607
PMID: 30500539
Sampaziotis et al. (2017) Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 12:814
PMID: 28333915
Pinheiro et al. (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res.Bull.. 124:222
PMID: 27208730
Knutson et al. (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One. 9:e111840
PMID: 25493630
Bullers et al. (2014) The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A. 20:2390
PMID: 24548290
Carbone et al. (2012) R.zole elevates GLT-1 activity and levels in striatal astrocytes. J Neurosci. 60:42613
PMID: 22080156

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Customer Reviews for Dexamethasone (1)

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Great anti-inflammatory drug

Name: Luiz Alexandre Magno

Species: Mouse

Assay Type: In Vivo

I used this drug to decrease the levels of IL-1, which is a proinflammatory cytokine. By doing this, we can explore the outcome of signalling pathways that can cause brain disease

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