Dexamethasone
Tocris Bioscience, part of Bio-Techne | Catalog # 1126
Anti-inflammatory glucocorticoid
Key Product Details
Description
Anti-inflammatory glucocorticoid
Product Description
Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.
Dexamethasone synthesized to Ancillary Material Grade also available.
Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
Product Specifications
Molecular Weight
392.47
Formula
C22H29FO5
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
CAS Number
50-02-2
PubChem ID
9830630
InChI Key
UREBDLICKHMUKA-WNYCSEIESA-N
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.25 | 100 |
Preparing Stock Solutions
for Dexamethasone
The following data is based on the product molecular weight 392.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.10 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Deng The effect of dexamethasone on lentiviral vector infection is associated with importin α. Biomed.Rep. 2014 PMID: 24649085
- Seregin Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy. Mol.Ther. 2009 PMID: 19174760
- Huch Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 2015 PMID: 25533785
- Laane Cell death induced by dexameth. in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 2009 PMID: 19390558
- Teixeira Effects of dexameth. and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 1996 PMID: 8735633
- Sittichokechaiwut Short bouts of mechanical loading are as effective as dexameth. at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 2010 PMID: 20648425
- Matasic Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 1999 PMID: 10614771
Product Specific Notices for Dexamethasone
For research use only
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