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GF 109203X

Protein Kinase C Inhibitors Small Molecule
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0741/10
0741/1

Key Product Details

Description: Protein kinase C inhibitor
Alternative Names: Gö 6850, Bisindolylmaleimide I
Chemical Name: 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide
Purity: ≥98% (HPLC)
Molecular Weight: 412.49

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  • GF 109203X blocks PKA effects in hippocampal neurons
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    GF 109203X (GF-109) was used to clarify an impact of PKC on average open time of GABA-A receptor channel. Experiment on outside-out membrane patches (OOP) and nucleated patches (NP) excised from hippocampal granule cells displayed a significant effect of GF-109 in NPs only. This confirms modulation of GABA-A receptor opening by PKA and ensures absence of GF-109 side effects on GABA-A receptors (since no effect was observed in OOPs).
    GF 109203X Serum 0741

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