GF 109203X

Citations are publications that use Bio-Techne products. Selected citations for GF 109203X include:

• Wijerathne et al. (2019) Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner. Korean J Physiol Pharmacol. 23:381
  PMID: 31496875
• Zhong (2018) Intracellular emetic signaling evoked by the L-type Ca²⁺ channel agonist FPL64176 in the least shrew (Cryptotis parva). Eur J Pharmacol. 834:157
  PMID: 29966616
• Schaffer et al. (2018) PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 25:2470
  PMID: 30485813
• O'Neill and Sylantyev (2018) Selective modulation of tonically active GABA_A receptor functional subgroups by G-proteins and protein kinase C. . 243:1046
  PMID: 30205722
• Fish et al. (2017) Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 144:2428
  PMID: 28536097
• Jantarajit et al. (2017) CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K⁺ channels. Am J Physiol Cell Physiol. 313:C118
  PMID: 28490422
• Al-Bayati et al. (2016) Effects of thrombin on Ins signalling and glucose uptake in cultured human myotubes. J.Diabetes Complications.. 30:1209
  PMID: 27396242
• Qu et al. (2016) Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine. World J Gastrointest Pathophysiol. 7:150
  PMID: 26909238
• Abedini et al. (2016) WNT5a is required for normal ovarian follicle development and antagonizes g.tropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 30:1534
  PMID: 26667040
• Yuan et al. (2015) Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 5:12889
  PMID: 26245668
• Devinney et al. (2015) Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. Int J Mol Sci. 35:8107
  PMID: 26019328
• Lin et al. (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. J Neurosci. 16:5555
  PMID: 25768340
• Seifert et al. (2015) Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways. Curr Alzheimer Res. 13:1909
  PMID: 26655905
• Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Am J Physiol Gastrointest Liver Physiol. 12:847
  PMID: 26510981
• Rattan and Ali (2015) Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle. BMC Res Notes. 308:G605
  PMID: 25617350
• Chen and Kan (2015) Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells. Biochim Biophys Acta. 1853:2662
  PMID: 26241492
• Yu et al. (2014) Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. J Exp Clin Cancer Res. 33:85
  PMID: 25261977
• Mitrugno et al. (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood. 123:249
  PMID: 24258815
• Wouters et al. (2014) Central role for protein kinase C in oxyt. and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells. J Pharmacol Exp Ther. 7:357
  PMID: 24916153
• Guemez-Gamboa et al. (2014) Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching. Neuron. 82:1004
  PMID: 24908484
• Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 111:1008
  PMID: 24335212
• Jahchan et al. (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 3:1364
  PMID: 24078773
• Copits and Swanson (2013) Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis. J Biol Chem. 288:8952
  PMID: 23400781
• Oh et al. (2013) Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening. Proc Natl Acad Sci U S A. 110:E305
  PMID: 23269840
• Khuituan et al. (2012) Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D₃-enhanced duodenal calcium transport in male mice. Am J Physiol Endocrinol Metab. 302:E903
  PMID: 22275752
• Hudson et al. (2012) Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1). Mol Hum Reprod. 18:265
  PMID: 22155728
• Meotti et al. (2012) Inflammatory muscle pain is dependent on the activation of kinin B₁ and B₂ receptors and intracellular kinase pathways. Br J Pharmacol. 166:1127
  PMID: 22220695
• Gao et al. (2012) Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse. J Neurosci. 61:1381
  PMID: 22492526
• Barbaric et al. (2011) High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival. J Biomol Screen. 16:603
  PMID: 21593487
• Zsombok et al. (2011) Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. Proc Natl Acad Sci U S A. 31:14024
  PMID: 21957263
• Lau et al. (2011) Apical and basolateral pools of proteinase-activated receptor-2 direct distinct signaling events in the intestinal epithelium. Am J Physiol Heart Circ Physiol. 300:C113
  PMID: 21068362
• Ajiro et al. (2011) Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. J Neurosci. 301:H2395
  PMID: 21949111
• Poteser et al. (2011) PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes. Cereb Cortex. 108:10556
  PMID: 21653882
• Riedl et al. (2009) Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. Cell Rep. 29:13377
  PMID: 19846725
• Freitas et al. (2009) Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle. Fundam Clin Pharmacol. 23:169
  PMID: 19298234
• Kim et al. (2008) Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds. Br J Pharmacol. 155:814
  PMID: 18724384
• Chung et al. (2007) IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4. J Endocrinol. 194:77
  PMID: 17592023
• Zapata et al. (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem. 282:35842
  PMID: 17923483
• Brager and Johnston (2007) Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons. J Neurosci. 27:13926
  PMID: 18094230
• Cobine et al. (2007) Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery. Am J Physiol Heart Circ Physiol. 292:H3079
  PMID: 17277031
• O'Riordan et al. (2006) Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors. Proc Natl Acad Sci U S A. 26:4870
  PMID: 16672661
• Jackson et al. (2005) Mechanism of the vascular angiotensin II/α2-adrenoceptor interaction. Am J Physiol Cell Physiol. 314:1109
  PMID: 15901799
• Corsini et al. (2003) Induction of adipose differentiation related protein and neutral lipid droplet accumulation in keratinocytes by skin irritants. J Invest Dermatol. 121:337
  PMID: 12880426
• Wibberley et al. (2003) Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle. Br J Pharmacol. 138:757
  PMID: 12642376
• Sano et al. (2000) Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways. J Neurosci. 97:13824
  PMID: 11087819

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• GF 109203X blocks PKA effects in hippocampal neurons

  Name: Anonymous
  Species: Rat
  Assay Type: In Vitro
  Cell Line/Tissue: Hippocampus
  GF 109203X (GF-109) was used to clarify an impact of PKC on average open time of GABA-A receptor channel. Experiment on outside-out membrane patches (OOP) and nucleated patches (NP) excised from hippocampal granule cells displayed a significant effect of GF-109 in NPs only. This confirms modulation of GABA-A receptor opening by PKA and ensures absence of GF-109 side effects on GABA-A receptors (since no effect was observed in OOPs).
  

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