Key Product Details
Description: | Protein kinase C inhibitor |
Alternative Names: | Gö 6850, Bisindolylmaleimide I |
Chemical Name: | 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 412.49 |
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Citations for GF 109203X (45)
Citations are publications that use Bio-Techne products. Selected citations for GF 109203X include:
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Wijerathne et al.
(2019)
Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner.
Korean J Physiol Pharmacol.
23:381
PMID: 31496875 -
Zhong
(2018)
Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva).
Eur J Pharmacol.
834:157
PMID: 29966616 -
Schaffer et al.
(2018)
PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
Cell Rep.
25:2470
PMID: 30485813 -
O'Neill and Sylantyev
(2018)
Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C.
.
243:1046
PMID: 30205722 -
Fish et al.
(2017)
Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network.
Development.
144:2428
PMID: 28536097 -
Jantarajit et al.
(2017)
CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels.
Am J Physiol Cell Physiol.
313:C118
PMID: 28490422 -
Al-Bayati et al.
(2016)
Effects of thrombin on Ins signalling and glucose uptake in cultured human myotubes.
J.Diabetes Complications..
30:1209
PMID: 27396242 -
Qu et al.
(2016)
Neurophysiological mechanisms of bradykinin-evoked mucosal chloride secretion in guinea pig small intestine.
World J Gastrointest Pathophysiol.
7:150
PMID: 26909238 -
Abedini et al.
(2016)
WNT5a is required for normal ovarian follicle development and antagonizes g.tropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
FASEB J.
30:1534
PMID: 26667040 -
Yuan et al.
(2015)
Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo.
Sci Rep.
5:12889
PMID: 26245668 -
Devinney et al.
(2015)
Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.
Int J Mol Sci.
35:8107
PMID: 26019328 -
Lin et al.
(2015)
Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
J Neurosci.
16:5555
PMID: 25768340 -
Seifert et al.
(2015)
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.
Curr Alzheimer Res.
13:1909
PMID: 26655905 -
Davis
(2015)
The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.
Am J Physiol Gastrointest Liver Physiol.
12:847
PMID: 26510981 -
Rattan and Ali
(2015)
Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle.
BMC Res Notes.
308:G605
PMID: 25617350 -
Chen and Kan
(2015)
Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.
Biochim Biophys Acta.
1853:2662
PMID: 26241492 -
Yu et al.
(2014)
Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells.
J Exp Clin Cancer Res.
33:85
PMID: 25261977 -
Mitrugno et al.
(2014)
A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.
Blood.
123:249
PMID: 24258815 -
Wouters et al.
(2014)
Central role for protein kinase C in oxyt. and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells.
J Pharmacol Exp Ther.
7:357
PMID: 24916153 -
Guemez-Gamboa et al.
(2014)
Non-cell-autonomous mechanism of activity-dependent neurotransmitter switching.
Neuron.
82:1004
PMID: 24908484 -
Zhao
(2014)
BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling.
J Neurophysiol.
111:1008
PMID: 24335212 -
Jahchan et al.
(2013)
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
Cancer Discov.
3:1364
PMID: 24078773 -
Copits and Swanson
(2013)
Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis.
J Biol Chem.
288:8952
PMID: 23400781 -
Oh et al.
(2013)
Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.
Proc Natl Acad Sci U S A.
110:E305
PMID: 23269840 -
Khuituan et al.
(2012)
Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D3-enhanced duodenal calcium transport in male mice.
Am J Physiol Endocrinol Metab.
302:E903
PMID: 22275752 -
Hudson et al.
(2012)
Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1).
Mol Hum Reprod.
18:265
PMID: 22155728 -
Meotti et al.
(2012)
Inflammatory muscle pain is dependent on the activation of kinin B1 and B2 receptors and intracellular kinase pathways.
Br J Pharmacol.
166:1127
PMID: 22220695 -
Gao et al.
(2012)
Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse.
J Neurosci.
61:1381
PMID: 22492526 -
Barbaric et al.
(2011)
High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival.
J Biomol Screen.
16:603
PMID: 21593487 -
Zsombok et al.
(2011)
Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice.
Proc Natl Acad Sci U S A.
31:14024
PMID: 21957263 -
Lau et al.
(2011)
Apical and basolateral pools of proteinase-activated receptor-2 direct distinct signaling events in the intestinal epithelium.
Am J Physiol Heart Circ Physiol.
300:C113
PMID: 21068362 -
Ajiro et al.
(2011)
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
J Neurosci.
301:H2395
PMID: 21949111 -
Poteser et al.
(2011)
PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes.
Cereb Cortex.
108:10556
PMID: 21653882 -
Riedl et al.
(2009)
Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.
Cell Rep.
29:13377
PMID: 19846725 -
Freitas et al.
(2009)
Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle.
Fundam Clin Pharmacol.
23:169
PMID: 19298234 -
Kim et al.
(2008)
Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds.
Br J Pharmacol.
155:814
PMID: 18724384 -
Chung et al.
(2007)
IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
J Endocrinol.
194:77
PMID: 17592023 -
Zapata et al.
(2007)
Regulation of DA transporter function and cell surface expression by D3 DA receptors.
J Biol Chem.
282:35842
PMID: 17923483 -
Brager and Johnston
(2007)
Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
J Neurosci.
27:13926
PMID: 18094230 -
Cobine et al.
(2007)
Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery.
Am J Physiol Heart Circ Physiol.
292:H3079
PMID: 17277031 -
O'Riordan et al.
(2006)
Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors.
Proc Natl Acad Sci U S A.
26:4870
PMID: 16672661 -
Jackson et al.
(2005)
Mechanism of the vascular angiotensin II/α2-adrenoceptor interaction.
Am J Physiol Cell Physiol.
314:1109
PMID: 15901799 -
Corsini et al.
(2003)
Induction of adipose differentiation related protein and neutral lipid droplet accumulation in keratinocytes by skin irritants.
J Invest Dermatol.
121:337
PMID: 12880426 -
Wibberley et al.
(2003)
Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle.
Br J Pharmacol.
138:757
PMID: 12642376 -
Sano et al.
(2000)
Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways.
J Neurosci.
97:13824
PMID: 11087819
There are no citations that match your criteria.
Customer Reviews for GF 109203X (1)
Customer Images
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Species: RatAssay Type: In VitroCell Line/Tissue: HippocampusGF 109203X (GF-109) was used to clarify an impact of PKC on average open time of GABA-A receptor channel. Experiment on outside-out membrane patches (OOP) and nucleated patches (NP) excised from hippocampal granule cells displayed a significant effect of GF-109 in NPs only. This confirms modulation of GABA-A receptor opening by PKA and ensures absence of GF-109 side effects on GABA-A receptors (since no effect was observed in OOPs).
There are no reviews that match your criteria.