Valproic acid, sodium salt

Product Description

Valproic acid, sodium salt is a histone deacetylase inhibitor (IC₅₀ = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na⁺ channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. Can induce autophagy by inhibiting inositol synthesis. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2. Enables generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from mouse embryonic fibroblasts (see our protocol below).

For more information about how Valproic acid, sodium salt may be used, see our protocol:

Highly Efficient Generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from Mouse Embryonic Fibroblasts (MEFs).

Solubility

Preparing Stock Solutions for Valproic acid, sodium salt

The following data is based on the product molecular weight 166.19

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.02 mL	30.09 mL	60.17 mL
5 mM	1.20 mL	6.02 mL	12.03 mL
10 mM	0.60 mL	3.01 mL	6.02 mL
50 mM	0.12 mL	0.60 mL	1.20 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
• Huangfu Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat.Biotechnol. 2008 PMID: 18849973
• Qing Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 2008 PMID: 18955571
• Kim Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 2007 PMID: 17371805
• Kostrouchova Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 2007 PMID: 17448293
• Phiel Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 2001 PMID: 11473107