Tunicamycin
Tocris Bioscience, part of Bio-Techne | Catalog # 3516
Antibiotic; GlcNAc phosphotransferase inhibitor
Key Product Details
Description
Antibiotic; GlcNAc phosphotransferase inhibitor
Product Description
Tunicamycin is an antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows:- Homolog A, n=8, C37H60N4O16, molecular weight = 816.90
- Homolog B, n=9, C38H62N4O16, molecular weight = 830.93
- Homolog C, n=10, C39H64N4O16, molecular weight = 844.95
- Homolog D, n=11, C40H66N4O16, molecular weight = 858.99
Product Specifications
Molecular Weight
844.95
Formula
C39H64N4O16 (tunicamycin C, n=10)
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
Tunicamycin from Streptomyces sp.
CAS Number
11089-65-9
PubChem ID
90488851
InChI Key
ZOCXUHJGZXXIGQ-SQXRCPDGSA-N
SMILES
O=C(C=C3)NC(N3[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)[C@H](O)C[C@@H]1[C@H](O)[C@H](O)[C@@H](NC(/C=C/CCCCCCCCCCC(C)C)=O)[C@H](OC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4NC(C)=O)O1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.25 | 50 |
Preparing Stock Solutions
for Tunicamycin
The following data is based on the product molecular weight 844.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.37 mL | 11.84 mL | 23.67 mL |
| 2.5 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 5 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 25 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lauer Primary murine airway smooth muscle cells exposed to poly(I:C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix. J.Biol.Chem. 2009 PMID: 19088077
- Ding Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 2007 PMID: 17135238
- Duriez The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated pathway. J.Biol.Chem. 2008 PMID: 18805786
Product Specific Notices for Tunicamycin
For research use only
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