Pepstatin A

Name: Pepstatin A
Brand: Tocris Bioscience
SKU: 1190
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1190

Citations (3)

(1)

COA / SDS

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Key Product Details

Description:	Selective and high affinity cathepsin D inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	685.91

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Biological Activity for Pepstatin A

Pepstatin A is an irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

Technical Data for Pepstatin A

M. Wt	685.91
Formula	C₃₄H₆₃N₅O₉
Single Letter Sequence	VVXAX (Modifications: Val-1 = N-terminal iso-Valeryl, X-3 = X-5 = Sta)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	26305-03-3
PubChem ID	5478883
InChi Key	FAXGPCHRFPCXOO-LXTPJMTPSA-N
Smiles	O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pepstatin A

Solubility

Soluble to 1mg/ml in ethanol with gentle warming

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References for Pepstatin A

References are publications that support the biological activity of the product.

Sato Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 2007 PMID: 17942897
Gacko Cathepsin D inhibitors. Folia Histochem.Cytobiol. 2007 PMID: 18165168
Mizuochi Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain. Immunol.Lett. 1997 PMID: 7721331
Marciniszyn Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 1976 PMID: 993206

Citations for Pepstatin A (3)

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Citations are publications that use Bio-Techne products. Selected citations for Pepstatin A include:

Berg et al. (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep. 27:2837
PMID: 31167131
Guerroue et al. (2017) Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 68:786
PMID: 29149599
Tsai et al. (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci. 4:e792
PMID: 24008736

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Customer Reviews for Pepstatin A (1)

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good performance

Name: Estela Correa

Species: Mouse

Assay Type: Ex Vivo

1:1000. Performed ideally

Leave in a container to prevent exposure to moisture.

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Product Documents for Pepstatin A

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.