Torin 1

Product Description

Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC₅₀ = 2 - 10 nM for mTORC1 and mTORC2). Torin 1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. In HeLa cells, Torin 1 induces autophagy. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1. In human monocytes and myeloid dendritic cells, Torin 1 prevents the anti-inflammatory effects of glucocorticoids. In the human endocrine cell line BON, Torin 1 increases neurotensin secretion and gene expression through MEK/ERK/c-Jun pathway activation.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Solubility

Preparing Stock Solutions for Torin 1

The following data is based on the product molecular weight 607.62

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.01 mM	164.58 mL	822.88 mL	1,645.77 mL
0.05 mM	32.92 mL	164.58 mL	329.15 mL
0.1 mM	16.46 mL	82.29 mL	164.58 mL
0.5 mM	3.29 mL	16.46 mL	32.92 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Weichhart Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 2011 PMID: 21368289
• Li mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Am.J.Physiol.Cell Physiol. 2011 PMID: 21508335
• Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
• Peterson mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 2011 PMID: 21816276
• Liu Discovery of 1-(4(-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J.Med.Chem. 2010 PMID: 20860370
• Thoreen An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J.Biol.Chem. 2009 PMID: 19150980
• Guertin and Sabatini The pharmacology of mTOR inhibition. Sci.Signal. 2009 PMID: 19383975