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Thapsigargin

Tocris Bioscience a Bio-Techne Brand

Ca2+-ATPase Inhibitors Small Molecule
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Key Product Details

Description: Potent inhibitor of SERCA ATPase
Chemical Name: (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
Purity: ≥97% (HPLC)
Molecular Weight: 650.76

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Citations for Thapsigargin (42)

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Customer Reviews for Thapsigargin (7)

4.4 out of 5
7 customer ratings
5 stars
57%
4 stars
29%
3 stars
14%
2 stars
0%
1 star
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  • Good activator for SOCE
    Name: Yuyang Sun
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Macrophage
    This product significantly induced calcium release and store operated calcium entry.
    Thapsigargin Serum 1138
  • Usage Information
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: KMS11 or OPM2
    100 nM
    Dissolved in DMSO. We treated cells for 16 hr.
    Thapsigargin Serum 1138
  • Thapsigargin Blocks Re-Uptake of Ca2+ Into ER leading to increased T-cell activation by IFNg
    Name: Li Zhu
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Primary Cd8+ T-cell
    Thapsigargin was used to block SERCA in activated CD8+ T-cells. This maintained high intracellular Ca2+, leading to increased activation of CD8+ T-cells as measured by IFNg production via intracellular flow cytometry.
    Thapsigargin Serum 1138
  • Intracellular calcium depletion
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    This compound is often used to deplete intracellular calcium stores in cell culture or other applications. It worked as expected in our tissue preparations.
  • Thapsigargin elicits store-operated Ca2+ entry after ER store depletion in RBL-2H3 cells.
    Name: Niroj Shrestha
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: RBL-2H3
    Cytosolic Ca2+ sensitive indicator, Fura-2 was loaded in RBL-2H3 cells and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm.ER store was depleted with 500 nM thapsigargin which promotes store-operated Ca2+ entry via STIM1/Orai1 pathway into the cells upon addition of 2 mM extracellular Ca2+.RBL-2H3 cells were loaded with FURA-2AM (2 μM) and Pluronic F127 (0.02%) for 30 min followed by washing with normal-Tyrode solution. Cells were stimulated at 1 Hz frequency and fluorescence intensities were measured.
    Thapsigargin Serum 1138
  • XBP1 splicing
    Name: Preethi Vijayaraj
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: mesenchymal cells
    Used it as a positive control to test if the mechanism of a novel small molecule (compound x) was to reduce ER stress. Cells were treated with 5um Thapsigargin for 24 hours, and splicing of XBP1 was determined by semi-quantitative RT-PCR
    Thapsigargin Serum 1138
  • Thapsigargin calcium assay
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK 293T
    for calcium release from the ER

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Product Documents for Thapsigargin

Certificate of Analysis

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