PI 103 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2930

Inhibitor of PI 3-kinase, mTOR and DNA-PK
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Key Product Details

Description

Inhibitor of PI 3-kinase, mTOR and DNA-PK

View all PI 3-Kinase Inhibitors »

Product Description

PI 103 hydrochloride is an inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.

Product Specifications

Molecular Weight

384.82

Formula

C19H16N4O3.HCl

Storage

Store at +4°C

Purity

≥97% (HPLC)

Chemical Name

3-[4-(4-Morpholinylpyridofuro[3,2-d]pyrimidin-2-yl]phenol hydrochloride

CAS Number

371935-79-4

PubChem ID

16739368

InChI Key

XSQMYBFFYPTMFE-UHFFFAOYSA-N

SMILES

OC1=CC(C(N=C4N5CCOCC5)=NC3=C4OC2=NC=CC=C23)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.7 20

Preparing Stock Solutions for PI 103 hydrochloride

The following data is based on the product molecular weight 384.82

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.99 mL 64.97 mL 129.93 mL
1 mM 2.60 mL 12.99 mL 25.99 mL
2 mM 1.30 mL 6.50 mL 12.99 mL
10 mM 0.26 mL 1.30 mL 2.60 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PI 103 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PI 103 hydrochloride

For research use only

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