Apoptosis Inducer Compounds Products
Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases. These apoptosis inducers can target specific cellular processes to induce antitumor or antineoplastic effects.
28 results for "Apoptosis Inducer Compounds" in Products
28 results for "Apoptosis Inducer Compounds" in Products
Apoptosis Inducer Compounds Products
Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases. These apoptosis inducers can target specific cellular processes to induce antitumor or antineoplastic effects.
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
| Chemical Name: | 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione |
| Purity: | ≥98% (HPLC) |
DNA cross-linking antitumor agent
| Alternate Names: | Ametycine |
| Chemical Name: | [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione |
| Purity: | ≥98% (HPLC) |
Potent pro-apoptotic anticancer agent; activates caspase-3
| Alternate Names: | CDDP |
| Chemical Name: | cis-Diaminodichloroplatinum |
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
| Alternate Names: | Adriamycin,NSC 123127 |
| Chemical Name: | 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride |
| Purity: | ≥98% (HPLC) |
Alkylating agent; chemotherapeutic
| Chemical Name: | 2-[bis(2-Chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide |
| Purity: | ≥98% (HPLC) |
DNA cross-linking antitumor agent
| Alternate Names: | Eloxatin |
| Chemical Name: | Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II) |
| Purity: | ≥98% (HPLC) |
Inhibits RNA polymerase
| Chemical Name: | 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide |
| Purity: | ≥95% (HPLC) |
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
| Chemical Name: | 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide |
| Purity: | ≥98% (HPLC) |
Suppressor of MDK expression; inhibits PI 3-K signaling
| Chemical Name: | 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one |
| Purity: | ≥98% (HPLC) |
Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis
| Chemical Name: | 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
DNA-methylating antitumor agent
| Alternate Names: | NSC 362856,CCRG 81045 |
| Chemical Name: | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide |
| Purity: | ≥98% (HPLC) |
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
| Chemical Name: | (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid |
Hypoxia-activated DNA alkylating agent prodrug
| Chemical Name: | (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate |
| Applications: | AdAct |
| Purity: | ≥98% (HPLC) |
DNA cross-linking antitumor agent
| Alternate Names: | NSC 241240,Paraplatin,JM 8 |
| Chemical Name: | cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) |
| Purity: | ≥98% (HPLC) |
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
| Chemical Name: | 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide |
| Purity: | ≥98% (HPLC) |
DNA alkylator; antitumor and induces diabetes
| Alternate Names: | Streptozotocin |
| Chemical Name: | 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose |
| Purity: | ≥95% (HPLC) |
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
| Alternate Names: | Kempferol |
| Chemical Name: | 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
| Chemical Name: | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
| Purity: | ≥98% (HPLC) |
Purine analog; inhibits DNA synthesis
| Chemical Name: | 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine |
| Purity: | ≥98% (HPLC) |
Potent and selective MEK inhibitor; orally bioavailable
| Chemical Name: | N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide |
| Purity: | ≥98% (HPLC) |
Pan-histone deacetylase inhibitor
| Chemical Name: | (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| Purity: | ≥98% (HPLC) |
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
| Chemical Name: | (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one |
| Purity: | ≥98% (HPLC) |
Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry
| Chemical Name: | 5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥95% (HPLC) |
High affinity and selective activator of Bax
| Chemical Name: | 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol |
| Purity: | ≥98% (HPLC) |
Potent pan-HDAC inhibitor
| Chemical Name: | (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide |
| Purity: | ≥98% (HPLC) |
