Streptozocin
Tocris Bioscience, part of Bio-Techne | Catalog # 1621
DNA alkylator; antitumor and induces diabetes
Key Product Details
Description
DNA alkylator; antitumor and induces diabetes
Alternative Names
Streptozotocin
Product Description
Streptozocin is an antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.Product Specifications
Molecular Weight
265.22
Formula
C8H15N3O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
CAS Number
18883-66-4
PubChem ID
2733335
InChI Key
ZSJLQEPLLKMAKR-YDEIVXIUSA-N
SMILES
O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(N(C)N=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.52 | 100 | |
| DMSO | 26.52 | 100 |
Preparing Stock Solutions
for Streptozocin
The following data is based on the product molecular weight 265.22
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.77 mL | 18.85 mL | 37.70 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Weis Steptozotocin: A review of its pharmacology, efficacy and toxicity. Cancer Treat. Rep. 1982 PMID: 6277485
- Bennett and Pegg Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 PMID: 6454479
Product Specific Notices for Streptozocin
For research use only
⚠ WARNING: This product can expose you to chemicals including Streptozocin (streptozotocin), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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