iMDK
Tocris Bioscience, part of Bio-Techne | Catalog # 5126
Suppressor of MDK expression; inhibits PI 3-K signaling
Key Product Details
Description
Suppressor of MDK expression; inhibits PI 3-K signaling
Product Description
iMDK is a suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.Product Specifications
Molecular Weight
376.40
Formula
C21H13FN2O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one
CAS Number
881970-80-5
PubChem ID
15991416
InChI Key
IWFKQTWYILKFGE-UHFFFAOYSA-N
SMILES
FC(C=C5)=CC=C5CC4=CN1C(S4)=NC(C(C(O3)=O)=CC2=C3C=CC=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.88 | 5 |
Preparing Stock Solutions
for iMDK
The following data is based on the product molecular weight 376.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 53.13 mL | 265.67 mL | 531.35 mL |
| 0.25 mM | 10.63 mL | 53.13 mL | 106.27 mL |
| 0.5 mM | 5.31 mL | 26.57 mL | 53.13 mL |
| 2.5 mM | 1.06 mL | 5.31 mL | 10.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hao Inhibition of the growth factor MDK/Midkine by a novel small molecule compound to treat non-small cell lung cancer. PLoS ONE 2013 PMID: 23976985
Product Specific Notices for iMDK
For research use only
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