STOCK2S 26016

Tocris Bioscience, part of Bio-Techne | Catalog # 5570

Lysine deficient protein kinase (WNK) signaling inhibitor
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Key Product Details

Description

Lysine deficient protein kinase (WNK) signaling inhibitor

View all Other Kinase Inhibitors »

Product Description

STOCK2S 26016 is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively. Inhibits STK39 activation; inhibits migration and invasion of cancer cells in vitro.

Product Specifications

Molecular Weight

333.38

Formula

C20H19N3O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

7-Ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine

CAS Number

332922-63-1

PubChem ID

3135086

InChI Key

PGNWQNJXXLPZEL-UHFFFAOYSA-N

SMILES

NC1=C2C(C=CC(OCC)=C2)=NC3=C1C=CC(NCC4=CC=CO4)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.34 100
Ethanol 16.67 50

Preparing Stock Solutions for STOCK2S 26016

The following data is based on the product molecular weight 333.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.00 mL 15.00 mL 30.00 mL
5 mM 0.60 mL 3.00 mL 6.00 mL
10 mM 0.30 mL 1.50 mL 3.00 mL
50 mM 0.06 mL 0.30 mL 0.60 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for STOCK2S 26016

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for STOCK2S 26016

For research use only

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