ABT 737
Tocris Bioscience, part of Bio-Techne | Catalog # 6835
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
Key Product Details
Description
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
Product Description
ABT 737 is a high affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.Product Specifications
Molecular Weight
813.43
Formula
C42H45ClN6O5S2
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
CAS Number
852808-04-9
PubChem ID
11228183
InChI Key
HPLNQCPCUACXLM-PGUFJCEWSA-N
SMILES
CN(CC[C@@H](NC1=C([N+]([O-])=O)C=C(S(=O)(NC(C2=CC=C(N3CCN(CC3)CC4=C(C5=CC=C(C=C5)Cl)C=CC=C4)C=C2)=O)=O)C=C1)CSC6=CC=CC=C6)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 81.34 | 100 |
Preparing Stock Solutions
for ABT 737
The following data is based on the product molecular weight 813.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.23 mL | 6.15 mL | 12.29 mL |
| 5 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 10 mM | 0.12 mL | 0.61 mL | 1.23 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.25 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- van Delft, MF The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006 PMID: 17097561
- Kline ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia 2007 PMID: 17460700
- Oltersdorf An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005 PMID: 15902208
Product Specific Notices for ABT 737
For research use only
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