Fludarabine

Tocris Bioscience, part of Bio-Techne | Catalog # 3495

Purine analog; inhibits DNA synthesis
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Key Product Details

Description

Purine analog; inhibits DNA synthesis

View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

Fludarabine is a purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

Product Specifications

Molecular Weight

285.23

Formula

C10H12FN5O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

CAS Number

21679-14-1

PubChem ID

657237

InChI Key

HBUBKKRHXORPQB-FJFJXFQQSA-N

SMILES

O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(F)=NC(N)=C2N=C3)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.52 100

Preparing Stock Solutions for Fludarabine

The following data is based on the product molecular weight 285.23

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.70 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.70 mL

Calculators

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Product Documents for Fludarabine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fludarabine

For research use only

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