Narciclasine
Tocris Bioscience, part of Bio-Techne | Catalog # 3715
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
Key Product Details
Description
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
Product Description
Narciclasine is an exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.Product Specifications
Molecular Weight
307.26
Formula
C14H13NO7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
CAS Number
29477-83-6
PubChem ID
72376
InChI Key
LZAZURSABQIKGB-AEKGRLRDSA-N
SMILES
OC1=C(C(N[C@]4([H])C3=C[C@H](O)[C@@H](O)[C@H]4O)=O)C3=CC2=C1OCO2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.73 | 100 |
Preparing Stock Solutions
for Narciclasine
The following data is based on the product molecular weight 307.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.27 mL | 32.55 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ingrassia Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents. J.Med.Chem. 2009 PMID: 19199649
- Lefranc Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol.Cancer Ther. 2009 PMID: 19531573
- Dumont The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 2007 PMID: 17898872
Product Specific Notices for Narciclasine
For research use only
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