Carboplatin
Tocris Bioscience, part of Bio-Techne | Catalog # 2626
DNA cross-linking antitumor agent
Key Product Details
Description
DNA cross-linking antitumor agent
Alternative Names
NSC 241240,Paraplatin,JM 8
Product Description
Carboplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).Product Specifications
Molecular Weight
371.25
Formula
C6H12N2O4Pt
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
CAS Number
41575-94-4
PubChem ID
10339178
InChI Key
OLESAACUTLOWQZ-UHFFFAOYSA-L
SMILES
O=C(C21CCC2)O[Pt-2]([NH3+])([NH3+])OC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.28 | 25 |
Preparing Stock Solutions
for Carboplatin
The following data is based on the product molecular weight 371.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.77 mL | 53.87 mL | 107.74 mL |
| 1.25 mM | 2.15 mL | 10.77 mL | 21.55 mL |
| 2.5 mM | 1.08 mL | 5.39 mL | 10.77 mL |
| 12.5 mM | 0.22 mL | 1.08 mL | 2.15 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thomas High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisp. but not carbop. ototoxicity. Mol.Pharmacol. 2006 PMID: 16569706
- Yang Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks. Radiation Res.
- Natarajan Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem.Pharmacol. 1999 PMID: 10535754
Product Specific Notices for Carboplatin
For research use only
⚠ WARNING: This product can expose you to chemicals including Carboplatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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