Cisplatin

Name: Cisplatin
Brand: Tocris Bioscience
SKU: 2251
Rating: 5 (7 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2251

(7)

Citations (169)

COA / SDS

Potent pro-apoptotic anticancer agent; activates caspase-3

Key Product Details

Description:	Potent pro-apoptotic anticancer agent; activates caspase-3
Alternative Names:	CDDP
Chemical Name:	cis-Diaminodichloroplatinum
Molecular Weight:	300.05

View Full Technical Details for Cisplatin

Technical Data
Citations / Reviews (7)

Biological Activity for Cisplatin

Cisplatin is a potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.

Technical Data for Cisplatin

M. Wt	300.05
Formula	Cl₂H₆N₂Pt
Storage	Store at RT
CAS Number	15663-27-1
PubChem ID	84691
InChi Key	LXZZYRPGZAFOLE-UHFFFAOYSA-L
Smiles	N.N.[Cl-].[Cl-].[Pt++]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cisplatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.5	5 with gentle warming

Preparing Stock Solutions for Cisplatin

The following data is based on the product molecular weight 300.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	66.66 mL	333.28 mL	666.56 mL
0.25 mM	13.33 mL	66.66 mL	133.31 mL
0.5 mM	6.67 mL	33.33 mL	66.66 mL
2.5 mM	1.33 mL	6.67 mL	13.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Cisplatin

References are publications that support the biological activity of the product.

Duan Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisp. and tumor necrosis factor α. Clin.Cancer Res. 2004 PMID: 14734475
Nomura Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells. Urol.Oncology
Seki Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother.Pharmacol. 2000 PMID: 10663637

Product Documents for Cisplatin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Cisplatin, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov