PCI 34051

Name: PCI 34051
Brand: Tocris Bioscience
SKU: 4643
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4643

Citations (1)

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent and selective HDAC8 inhibitor
Chemical Name:	N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	296.32

View Full Technical Details for PCI 34051

Biological Activity for PCI 34051

PCI 34051 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC₅₀ = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.

Compound Libraries for PCI 34051

PCI 34051 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PCI 34051

M. Wt	296.32
Formula	C₁₇H₁₆N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	950762-95-5
PubChem ID	24753719
InChi Key	AJRGHIGYPXNABY-UHFFFAOYSA-N
Smiles	O=C(NO)C1=CC=C2C(N(CC3=CC=C(OC)C=C3)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PCI 34051

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.63	100
	1eq. NaOH	5.93	20

Preparing Stock Solutions for PCI 34051

The following data is based on the product molecular weight 296.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.37 mL	16.87 mL	33.75 mL
5 mM	0.67 mL	3.37 mL	6.75 mL
10 mM	0.34 mL	1.69 mL	3.37 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for PCI 34051

References are publications that support the biological activity of the product.

Pipalia Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 21436030
Balasubramanian A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 2008 PMID: 18256683

Citations for PCI 34051 (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for PCI 34051 include:

Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition Br J?Cancer. 118(10):1359
PMID: 29695769

There are no citations that match your criteria.

Showing 1 - 1 of 1 citation Showing All

Customer Reviews for PCI 34051 (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

responder treated with 5 μM PCI34051 (HDAC 8 inhibitor) for 48 h. Cell lysates were analysed by western blot.

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: C3-TAg tumour cell

TGF beta high responder treated with 5 μM PCI34051 (HDAC 8 inhibitor) for 48 h. Cell lysates were analysed by western blot.

PMID: 29695769

There are no reviews that match your criteria.