C 75
Tocris Bioscience, part of Bio-Techne | Catalog # 2489
Potent fatty acid synthase inhibitor; proapoptotic
Key Product Details
Description
Potent fatty acid synthase inhibitor; proapoptotic
Alternative Names
trans-C 75
Product Description
C 75 is a synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits antitumor activity.Product Specifications
Molecular Weight
254.32
Formula
C14H22O4
Storage
Store at +4°C
Purity
≥94% (HPLC)
Chemical Name
(2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
CAS Number
191282-48-1
PubChem ID
90488767
InChI Key
VHOGWRFOUWVZQX-FBVLPHPLSA-N
SMILES
C=C([C@@H]([C@](O)=O)[C@H](CCCCCCCC)O1)C1=O.C=C([C@H](C(O)=O)[C@@H](CCCCCCCC)O2)C2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.43 | 100 | |
| 1eq. NaOH | 25.43 | 100 |
Preparing Stock Solutions
for C 75
The following data is based on the product molecular weight 254.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.93 mL | 19.66 mL | 39.32 mL |
| 5 mM | 0.79 mL | 3.93 mL | 7.86 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.93 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thupari Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab.
- Takahashi The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 2004 PMID: 14512433
- Kuhajda Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci.
- Zhou Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003 PMID: 14612531
Product Specific Notices for C 75
For research use only
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