Oxaliplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Product Specifications

Molecular Weight

397.29

Formula

C₈H₁₄N₂O₄Pt

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)

CAS Number

61825-94-3

PubChem ID

9887054

InChI Key

ZROHGHOFXNOHSO-BNTLRKBRSA-L

SMILES

[Pt++].[O-]C(=O)C([O-])=O.[H][C@@]1(N)CCCC[C@@]1([H])N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.99	5 with gentle warming

Preparing Stock Solutions for Oxaliplatin

The following data is based on the product molecular weight 397.29

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	50.34 mL	251.71 mL	503.41 mL
0.25 mM	10.07 mL	50.34 mL	100.68 mL
0.5 mM	5.03 mL	25.17 mL	50.34 mL
2.5 mM	1.01 mL	5.03 mL	10.07 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Raymond Cellular and molecular pharmacology of oxalip. Mol.Cancer Ther. 2002 PMID: 12467217
Mani Oxaliplatin: a review of evolving concepts. Cancer Invest. 2002 PMID: 11901545
Culy Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies. Drugs 2000 PMID: 11085200

Oxaliplatin

Tocris Bioscience, part of Bio-Techne | Catalog # 2623

Key Product Details

Description

Alternative Names

View all Apoptosis Inducer Compounds »

Product Description