Oxaliplatin

Name: Oxaliplatin
Brand: Tocris Bioscience
SKU: 2623
Rating: 5 (2 reviews)

Catalog # 2623 | Tocris Bioscience a Bio-Techne Brand

(2)

Citations (7)

COA / SDS

DNA cross-linking antitumor agent

Key Product Details

Description:	DNA cross-linking antitumor agent
Alternative Names:	Eloxatin
Chemical Name:	Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Purity:	≥99% (HPLC)
Molecular Weight:	397.29

View Full Technical Details for Oxaliplatin

Technical Data
Citations (7) / Reviews (2)

Biological Activity for Oxaliplatin

Oxaliplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Technical Data for Oxaliplatin

M. Wt	397.29
Formula	C₈H₁₄N₂O₄Pt
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	61825-94-3
PubChem ID	9887054
InChi Key	ZROHGHOFXNOHSO-BNTLRKBRSA-L
Smiles	[Pt++].[O-]C(=O)C([O-])=O.[H][C@@]1(N)CCCC[C@@]1([H])N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oxaliplatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.99	5 with gentle warming

Preparing Stock Solutions for Oxaliplatin

The following data is based on the product molecular weight 397.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	50.34 mL	251.71 mL	503.41 mL
0.25 mM	10.07 mL	50.34 mL	100.68 mL
0.5 mM	5.03 mL	25.17 mL	50.34 mL
2.5 mM	1.01 mL	5.03 mL	10.07 mL

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References for Oxaliplatin

References are publications that support the biological activity of the product.

Raymond Cellular and molecular pharmacology of oxalip. Mol.Cancer Ther. 2002 PMID: 12467217
Mani Oxaliplatin: a review of evolving concepts. Cancer Invest. 2002 PMID: 11901545
Culy Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies. Drugs 2000 PMID: 11085200

Citations for Oxaliplatin (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Oxaliplatin include:

Massey (2015) Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS One. 10:e0134306
PMID: 26218638
Fukushima et al. (2015) Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci. 106:1000
PMID: 26017781
Li et al. (2015) FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. BMC Cancer. 6:9240
PMID: 25860929
Bryant et al. (2014) Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. Exp Neurol. 14:570
PMID: 25104095
Rawlinson (2014) γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments. BMC Cancer. 14:483
PMID: 24996846
Ibáñez et al. (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen. 15:359
PMID: 22256970
Boyette-Davis and Dougherty (2011) Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by MinCyc. Oncotarget. 229:353
PMID: 21385581

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Customer Reviews for Oxaliplatin (2)

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Oxaliplatin induced immunogenic cell death in HCT116 cells

Name: Tahmineh Safaie

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: HCT116

HCT116 cells were treated with 600 uM of Oxaliplatin for 4 hours and up regulation of surface expression of calreticulin was measured.
Oxaliplatin effectively kills melanoma cell growth in vitro

Name: Anonymous

Species: Human

Assay Type: In Vitro

Oxaliplatin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

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