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Ubiquitin Ligase (E3) Inhibitors: Small Molecules and Peptides

40 results for "Ubiquitin Ligase (E3) Inhibitors Small Molecules and Peptides" in Products

40 results for "Ubiquitin Ligase (E3) Inhibitors Small Molecules and Peptides" in Products

Ubiquitin Ligase (E3) Inhibitors: Small Molecules and Peptides

SPOP E3 ubiquitin ligase inhibitor

Chemical Name: 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide
Purity: ≥98% (HPLC)
SPOP E3 ubiquitin ligase inhibitor

HECT E3 ubiquitin ligase inhibitor

Chemical Name: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity: ≥98% (HPLC)
HECT E3 ubiquitin ligase inhibitor

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity: ≥98% (HPLC)
Cereblon binder; induces ubiquitination and degradation of CK1α by  E3 ubiquitin ligase

High-affinity inhibitor of VHL

Chemical Name: (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
High-affinity inhibitor of VHL

CHIP/STUB1 E3 ligase inhibitor

Purity: ≥95% (HPLC)
CHIP/STUB1 E3 ligase inhibitor

MDM2-p53 interaction inhibitor

Alternate Names: NSC 652287
Chemical Name: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
Purity: ≥97% (HPLC)
MDM2-p53 interaction inhibitor

β-TrCP1 ligase inhibitor

Chemical Name: 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Purity: ≥98% (HPLC)
β-TrCP1 ligase inhibitor

Selective Skp2 inhibitor; suppresses E3 ligase activity

Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Selective Skp2 inhibitor; suppresses E3 ligase activity

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

Chemical Name: (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Application of MZ 1 in HeLa Cells
(2)

Cereblon binder; also TNF-α inhibitor and antiangiogenic

Chemical Name: 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Cereblon binder; also TNF-α inhibitor and antiangiogenic

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
Purity: ≥98% (HPLC)
Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Potent and selective CSN5 (COP9 signalosome) inhibitor

Chemical Name: 3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide
Purity: ≥98% (HPLC)
Novartis vs Bio-Techne batch comparison for CSN5i-3
(2)

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

Chemical Name: 4-[[(4S,5R)-4,5-bis(4-Chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Purity: ≥97% (HPLC)
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

Chemical Name: N-(4-Butyl-2-methylphenyl)acetamide
Purity: ≥98% (HPLC)
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase

Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

Chemical Name: 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid
Purity: ≥98% (HPLC)
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

Homo-PROTAC® for self-degradation of pVHL30

Chemical Name: N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
Purity: ≥98% (HPLC)
Homo-PROTAC® for self-degradation of pVHL30

Selective CUL4 inhibitor

Chemical Name: 3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Selective CUL4 inhibitor

(+)-JQ1 based PROTAC® with selectivity for BRD4

Chemical Name: (2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide
Purity: ≥98% (HPLC)
(+)-JQ1 based PROTAC® with selectivity for BRD4

Hdm2 inhibitor; activates p53-dependent transcription

Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
Purity: ≥98% (HPLC)
Hdm2 inhibitor; activates p53-dependent transcription

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione
Purity: ≥98% (HPLC)
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

MDM2 antagonist; inhibits MDM2-p53 interaction

Chemical Name: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Purity: ≥98% (HPLC)
MDM2 antagonist; inhibits MDM2-p53 interaction

RNF114 inhibitor

Chemical Name: (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-Furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-2H,5H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
Purity: ≥97% (HPLC)
RNF114 inhibitor

High affinity MDM2 inhibitor

Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Purity: ≥98% (HPLC)
High affinity MDM2 inhibitor

VHL inhibitor

Chemical Name: (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥97% (HPLC)
VHL inhibitor

Inhibitor of VHL; blocks interaction of VHL and HIF-α

Chemical Name: (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Inhibitor of VHL; blocks interaction of VHL and HIF-α
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