CM 11
Tocris Bioscience, part of Bio-Techne | Catalog # 6416
Homo-PROTAC® for self-degradation of pVHL30
Key Product Details
Description
Homo-PROTAC® for self-degradation of pVHL30
Product Description
CM 11 is a PROTAC® for self-degradation of the long form of VHL, pVHL30 (DC50 < 100 nM). Composed of two VHL ligands joined by a linker. Exhibits > 1000-fold increased cellular activity compared to the parent VHL ligand, VH 032. Dimerizes pVHL30 with high avidity in vitro. Induced potent and rapid self-degradation of VHL in cell lines in a highly isoform dependent fashion.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under licence from the University of DundeeProduct Specifications
Molecular Weight
1179.46
Formula
C58H82N8O14S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
CAS Number
2244684-49-7
PubChem ID
134160242
InChI Key
WGJCHHJGGFCCRS-DEYDLUNASA-N
SMILES
CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 117.95 | 100 |
Preparing Stock Solutions
for CM 11
The following data is based on the product molecular weight 1179.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.85 mL | 4.24 mL | 8.48 mL |
| 5 mM | 0.17 mL | 0.85 mL | 1.70 mL |
| 10 mM | 0.08 mL | 0.42 mL | 0.85 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Maniaci Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Commun. 2017 PMID: 29018234
Product Specific Notices for CM 11
For research use only
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