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Active Degraders Products

Degraders are a way to knock down target proteins within cells. They are made up of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. These hybrid molecules induce selective, proteasome-dependent degradation of target proteins. Degraders be also used to investigate the downstream effects of protein knockdown or to interfere with specific signaling pathways.

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86 results for "Active Degraders" in Products

Active Degraders Products

Degraders are a way to knock down target proteins within cells. They are made up of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. These hybrid molecules induce selective, proteasome-dependent degradation of target proteins. Degraders be also used to investigate the downstream effects of protein knockdown or to interfere with specific signaling pathways.

Products:

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86 results for "Active Degraders" in Products

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Potent and selective BRD9 Degrader (PROTAC®)

Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

Potent TANK-binding kinase 1 (TBK1) PROTAC®

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

Selective and potent TAG Degrader for auxin-inducible degron 2 system

Selective peptide-based β-catenin Degrader (PROTAC®)

Degrader of MTH1 fusion proteins for use within the aTAG system

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Selective JAK2 Degrader (PROTAC®)

(+)-JQ1 based PROTAC® with selectivity for BRD4

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Potent and selective Wee1 Degrader (PROTAC®)

Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells

Degrader of MTH1 fusion proteins for use within the aTAG system

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

Selective KRAS Degrader (PROTAC®)

SRC-1 peptide-based Degrader (PROTAC®); active in vivo

Selective ALK Degrader (PROTAC®)

Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)

c-MET PROTAC®; also degrades exon-14-deleted c-MET

Potent and selective androgen receptor Degrader (PROTAC®)

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