NX 2127

Name: NX 2127
Brand: Tocris Bioscience
SKU: 8951

Tocris Bioscience, part of Bio-Techne | Catalog # 8951

COA / SDS

Potent BTK Degrader (PROTAC®)

Key Product Details

Description:	Potent BTK Degrader (PROTAC^®)
Chemical Name:	3-[[4-[1-[[(3R)-1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-pyrrolidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-(1-piperidinyl)-2-pyrazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	719.85

View Full Technical Details for NX 2127

Technical Data
Citations

Biological Activity for NX 2127

NX 2127 is a potent BTK Degrader (PROTAC^®) (DC₅₀ = 4.5 nM and D_max = 94%). It comprises a BTK binding moiety joined by a linker to a cereblon (CRBN) ligand. NX 2127 also degrades the transcription factors IKZF1 and IKZF3 (DC₅₀ = 57 and 36 nM, respectively). In vivo, NX 2127 possesses potent target degradation activity across species and demonstrates efficacy in preclinical oncology models. NX 2127 is orally bioavailable.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Nurix Therapeutics

Technical Data for NX 2127

M. Wt	719.85
Formula	C₃₉H₄₅N₉O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3024312-52-2
PubChem ID	167282486
InChi Key	XLWJWCMQMBVNSG-LZDHLTRGSA-N
Smiles	O=C1C2=CC(N3C[C@H](CC3)CN4CCC(C5=CC=C(C=C5)NC6=NC(N7CCCCC7)=CN=C6C(N)=O)CC4)=CC=C2C(N1C8C(NC(CC8)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NX 2127

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.99	50

Preparing Stock Solutions for NX 2127

The following data is based on the product molecular weight 719.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.78 mL	13.89 mL	27.78 mL
2.5 mM	0.56 mL	2.78 mL	5.56 mL
5 mM	0.28 mL	1.39 mL	2.78 mL
25 mM	0.06 mL	0.28 mL	0.56 mL

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References for NX 2127

References are publications that support the biological activity of the product.

Robbins Discovery and preclinical pharmacology of NX-2127, an orally bioavailable Degrader of Bruton's tyrosine kinase with immunomodulatory activity for the treatment of patients with B cell malignancies. J.Med.Chem. 2024 PMID: 38300987

Product Documents for NX 2127

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.