NX 5948
Tocris Bioscience, part of Bio-Techne | Catalog # 8856
Potent and selective BTK Degrader (PROTAC®)
Key Product Details
Description
Potent and selective BTK Degrader (PROTAC®)
Product Description
NX 5948 is a potent and selective Bruton's tyrosine kinase (BTK) Degrader (PROTAC®) (DC50 = <1 nM; Dmax = 98%). Comprises a BTK binding moiety joined by a linker to cereblon (CRBN) ligand. In vitro, NX-5948 very potently, rapidly and completely degrades BTK in primary human B cells (DC50 = 0.034 nM). NX 5948 degrades BTK, inhibits tumor growth and increases survival in TMD8 xenograft mouse models of brain maligancy. Reduces inflammation and symptom severity in a mouse model of collagen-induced arthritis. NX 5948 is orally bioavailable and blood brain barrier penetrant.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Nurix TherapeuticsProduct Specifications
Molecular Weight
806.97
Formula
C42H54N12O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-[[4-[1-[[1-[6-[[[(3S)-2,6-Dioxo-3-piperidinyl]amino]carbonyl]-3-pyridinyl]-4-piperidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-[(3R)-3-(3-methyl-2-oxo-1-imidazolidinyl)-1-piperidinyl]-2-pyrazinecarboxamide
CAS Number
2649400-34-8
PubChem ID
156464216
InChI Key
HPTPDBYCFHFWJG-CWTKIQHKSA-N
SMILES
NC(C1=C(N=C(N2C[C@H](N3C(N(CC3)C)=O)CCC2)C=N1)NC4=CC=C(C5CCN(CC5)CC6CCN(C7=CN=C(C(N[C@@H]8C(NC(CC8)=O)=O)=O)C=C7)CC6)C=C4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.35 | 50 |
Preparing Stock Solutions
for NX 5948
The following data is based on the product molecular weight 806.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.48 mL | 12.39 mL | 24.78 mL |
| 2.5 mM | 0.50 mL | 2.48 mL | 4.96 mL |
| 5 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 25 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for NX 5948
For research use only
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